数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

345878 Sigma-AldrichGGTI-286 - CAS 171744-11-9 - Calbiochem

GGTI-286, CAS 171744-11-9, is a cell-permeable, potent, and selective inhibitor of GGTase I. It is about 25-fold more potent (IC50 = 2 µM) than FTI-277 in inhibiting the processing of Rap1A protein.

GGTI-286 - CAS 171744-11-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet
Citations

同義語: N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA

Primary Target: Geranylgeranyltransferase (GGTase)

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
171744-11-9	C₂₃H₃₁N₃O₃S

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
345878-250UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	250 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC₅₀ = 2 µM vs. 50 µM) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC₅₀ = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.
Catalogue Number	345878
Brand Family	Calbiochem®
Synonyms	N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA

References
References	Bredel, M., et al. 1998. Neurosurgery 43, 124. Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293. Lerner, E.C., et al. 1997. Oncogene 15, 1283. Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26770.

Product Information
CAS number	171744-11-9
ATP Competitive	N
Form	Glassy solid
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₂₃H₃₁N₃O₃S
Chemical formula	C₂₃H₃₁N₃O₃S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	GGTI-286, CAS 171744-11-9, is a cell-permeable, potent, and selective inhibitor of GGTase I. It is about 25-fold more potent (IC50 = 2 µM) than FTI-277 in inhibiting the processing of Rap1A protein.

Biological Information
Primary Target	Geranylgeranyltransferase (GGTase)
Primary Target IC<sub>50</sub>	2 µM against GGTase
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
345878-250UGCN	04055977214505

Documentation

GGTI-286 - CAS 171744-11-9 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

GGTI-286 - CAS 171744-11-9 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
345878	ロット番号を入力

参考資料

参考資料の概要
Bredel, M., et al. 1998. Neurosurgery 43, 124. Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293. Lerner, E.C., et al. 1997. Oncogene 15, 1283. Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26770.

引用

Title

Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-March-2011 RFH
Synonyms	N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA
Description	A potent, cell-permeable, and selective GGTase-I inhibitor. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is 25-fold more potent (IC₅₀ = 2 µM versus 50 µM) than FTI-277 (Cat. No. 344555) inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC₅₀ = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells.
Form	Glassy solid
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	171744-11-9
Chemical formula	C₂₃H₃₁N₃O₃S
Structure formula
Purity	≥90% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
Toxicity	Standard Handling
References	Bredel, M., et al. 1998. Neurosurgery 43, 124. Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293. Lerner, E.C., et al. 1997. Oncogene 15, 1283. Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26770.
Citation	Karen E. Porter, et al. (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. Cardiovascular Research 61, 745-755.

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カタログ番号

説明

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価格＆在庫状況を表示

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors

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