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344270 Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem

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344270
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概要

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CAS #Empirical Formula
66575-29-9C₂₂H₃₄O₇

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カタログ番号 在庫状況包装 Qty/Pk 価格 数量
344270-10MGCN
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      344270-25MGCN
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          樹脂アンプル 25 mg
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          344270-50MGCN
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              Description
              OverviewThe major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
              Catalogue Number344270
              Brand Family Calbiochem®
              Synonyms7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin
              References
              ReferencesD'Orazio, J.A., et al. 2006. Nature 443, 340.
              Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
              Galli, C., et al. 1995. J. Neurosci. 15, 1172.
              Li, X., et al. 1995. Am. J. Physiol. 269, C986.
              Lomo, J., et al. 1995. J. Immunol. 154, 1634.
              Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
              Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
              Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
              Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
              Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
              Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
              Product Information
              CAS number66575-29-9
              ATP CompetitiveN
              FormWhite to off-white crystalline solid
              Hill FormulaC₂₂H₃₄O₇
              Chemical formulaC₂₂H₃₄O₇
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Biological Information
              Primary TargetAdenylate cyclase
              Primary Target IC<sub>50</sub>25 µM inhibiting MAP kinase in rat renal mesangial cells; EC50 = 4 µM for activation of adenylate cyclase
              Purity≥99% by HPLC
              Physicochemical Information
              Cell permeableY
              Safety Information according to GHS
              RTECSQL6150000
              Safety Information
              R PhraseR: 21

              Harmful in contact with skin.
              S PhraseS: 36

              Wear suitable protective clothing.
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +15°C to +30°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 4 months at 4°C.
              Global Trade Item Number
              カタログ番号 GTIN
              344270-10MGCN 07790788049294
              344270-25MGCN 04055977215359
              344270-50MGCN 04055977215366