数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

343021 Sigma-AldrichFlt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: Bis-(5-hydroxy-1H-indol-2-yl)methanone, PDGFR Tyrosine Kinase Inhibitor XI

Primary Target: Flt-3

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
896138-40-2	C₁₇H₁₂N₂O₃

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
343021-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	This product has been discontinued. A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC₅₀ = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC₅₀ = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC₅₀ = 4.2 and ≥0.5 µM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme's ATP-binding site.
Catalogue Number	343021
Brand Family	Calbiochem®
Synonyms	Bis-(5-hydroxy-1H-indol-2-yl)methanone, PDGFR Tyrosine Kinase Inhibitor XI

References
References	Mahboobi, S., et al. 2006. J. Med. Chem. 49, 3101.

Product Information
CAS number	896138-40-2
ATP Competitive	N
Form	Yellowish brown solid
Hill Formula	C₁₇H₁₂N₂O₃
Chemical formula	C₁₇H₁₂N₂O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Flt-3
Primary Target IC<sub>50</sub>	40 nM against Flt3 in cell-based receptor autophosphorylation; 33 nM against Flt3 in cell-free kinase reactions
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
343021-1MGCN	04055977195026

Documentation

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Flt-3 Inhibitor II - CAS 896138-40-2 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
343021	ロット番号を入力

参考資料

参考資料の概要
Mahboobi, S., et al. 2006. J. Med. Chem. 49, 3101.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-September-2007 JSW
Synonyms	Bis-(5-hydroxy-1H-indol-2-yl)methanone, PDGFR Tyrosine Kinase Inhibitor XI
Description	A cell-permeable symmetrical indolylmethanone kinase inhibitor that is more selective toward Flt3 over PDGFR either in cell-based receptor autophosphorylation (IC₅₀ = 40 nM vs. 300 nM) or in cell-free kinase reactions (IC₅₀ = 33 nM vs. 171 nM) and potently induces apoptosis in Flt3-expressing primary AML patient blasts. Affects Abl- or Kit-dependent cell growth only at much higher concentrations (IC₅₀ = 4.2 and ≥0.5 µM, respectively), while exhibiting little effect against IL-3-mediated cellular signaling. The molecular mechanism of inhibition is presumably due to interaction at the enzyme's ATP-binding site.
Form	Yellowish brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	896138-40-2
Chemical formula	C₁₇H₁₂N₂O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml) or Ethanol (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Mahboobi, S., et al. 2006. J. Med. Chem. 49, 3101.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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