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504843 Fbxo3 Inhibitor, BC-1215 - CAS 1507370-20-8 - Calbiochem

Fbxo3 Inhibitor, BC-1215 - CAS 1507370-20-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: N¹,N²-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator

Primary Target: Fbox3
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504843
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
1507370-20-8C₂₆H₂₆N₄

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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewA cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination. Effectively reduces cellular TRAFs (5 to 127 µM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25 µM). Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P. aeruginosa infection in mice (100 µg/mouse; i.p.) in vivo.
      Catalogue Number504843
      Brand Family Calbiochem®
      SynonymsN¹,N²-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator
      References
      ReferencesChen, B.B., et al. 2013. Nat. Immunol. 14, 470.
      Product Information
      CAS number1507370-20-8
      FormBeige solid
      Hill FormulaC₂₆H₂₆N₄
      Chemical formulaC₂₆H₂₆N₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFbox3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      5.04843.0001 04055977243604

      Documentation

      Fbxo3 Inhibitor, BC-1215 - CAS 1507370-20-8 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      参考資料

      参考資料の概要
      Chen, B.B., et al. 2013. Nat. Immunol. 14, 470.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsN¹,N²-bis(4-(Pyridin-2-yl)benzyl)ethane-1,2-diamine, F Box Only Protein 3 Inhibitor, F Box Protein 3 Inhibitor, BC1215, F Box and Leucine-rich Repeat Protein 2 Activator, Fbxl2 Activator
      DescriptionA cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction by targeting Fbxo3 C-terminal ApaG domain and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in upregulation of cellular Fbxl2 and thereby SCF-Fbxl2-catalyzed ubiquitination of TRAFs (TNF Receptor-Associated Factors). Effectively reduces cellular TRAFs in human macrophage U937, PBMC, and murine murine MLE cultures (16 to 18 h with 5 to 127 µM BC-1215), resulting in downregulation of TRAF-mediated cytokines production from LPS-stimulated human PBMC (2 µg/mL LPS; 25 µM BC-1215;16 h). Intraperitoneal injection in mice in vivo (100 µg/mouse) is shown to greatly prevent circulating proinflammatory cytokines increase post CLP (Cecal Ligation & Puncture) and substantially reduce the severity of cell infiltration in lung after intratracheal P. aeruginosa PA103 infection.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1507370-20-8
      Chemical formulaC₂₆H₂₆N₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, B.B., et al. 2013. Nat. Immunol. 14, 470.