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341610 FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem

The FGF/PDGF/VEGF RTK Inhibitor, also referenced under CAS 144335-37-5, controls the biological activity of FGF/PDGF/VEGF RTK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII

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341610
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
144335-37-5C₁₆H₁₁N₃O₂

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      Description
      OverviewA cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC50 = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC50 = 420 nM).
      Catalogue Number341610
      Brand Family Calbiochem®
      Synonyms4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII
      References
      ReferencesRenhowe, P.A., et al. 2009. J. Med. Chem. 52, 278.
      Product Information
      CAS number144335-37-5
      FormOff-white solid
      Hill FormulaC₁₆H₁₁N₃O₂
      Chemical formulaC₁₆H₁₁N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      341610-5MGCN 04055977194869

      Documentation

      FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      FGF/PDGF/VEGF RTK Inhibitor - CAS 144335-37-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      341610

      参考資料

      参考資料の概要
      Renhowe, P.A., et al. 2009. J. Med. Chem. 52, 278.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      Synonyms4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII
      DescriptionA cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC50 = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC50 = 420 nM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number144335-37-5
      Chemical formulaC₁₆H₁₁N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRenhowe, P.A., et al. 2009. J. Med. Chem. 52, 278.