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14-644 EphA3 Protein, active, 10 µg

14-644
10 µg  
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      概要

      Replacement Information
      Description
      Catalogue Number14-644
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionEphA3 Protein, active, 10 µg
      OverviewN-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman EphA3 amino acids 578-end, expressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.
      Gene Symbol
      • EPHA3
      • HEK4
      • ETK1
      • HEK
      • TYRO4
      • ETK
      • EphA3
      Protein TargetEphA3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29320 # Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
      SIZE: 983 amino acids; 110131 Da
      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
      TISSUE SPECIFICITY: Widely expressed. Highest level in placenta.
      DISEASE:SwissProt: P29320 # Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].
      SIMILARITY: SwissProt: P29320 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
      Molecular Weight49kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      14-644 04053252674952

      Documentation

      EphA3 Protein, active, 10 µg (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      EphA3 Protein, active, 10 µg 試験成績書(CoA)

      タイトルロット番号
      EphA3, active - 1634295-A 1634295-A

      参考資料

      参考資料の概要Pub Med ID
      EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion.
      Smith, Loraine M, et al.
      Exp. Cell Res., 292: 295-303 (2004)  2004

      概要を表示する
      14697337 14697337
      Multiple roles of EPH receptors and ephrins in neural development.
      Wilkinson, D G
      Nat. Rev. Neurosci., 2: 155-64 (2001)  2001

      概要を表示する
      11256076 11256076
      Eph receptors, ephrins, and PDZs gather in neuronal synapses.
      Hsueh, Y P and Sheng, M
      Neuron, 21: 1227-9 (1998)  1998

      9883715 9883715
      Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide.
      Ernst, A F, et al.
      Prog. Brain Res., 118: 115-31 (1998)  1998

      概要を表示する
      9932438 9932438