330005 Sigma-AldrichEST - CAS 88321-09-9 - Calbiochem
A cell-permeable, irreversible inhibitor of cysteine proteases.
More>> A cell-permeable, irreversible inhibitor of cysteine proteases. Less<<EST - CAS 88321-09-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
同義語: Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
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概要
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主要スペック表
| CAS # | Empirical Formula |
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| 88321-09-9 | C₁₇H₃₀N₂O₅ |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
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| 330005-1MGCN |
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樹脂ｱﾝﾌﾟﾙ | 1 mg |
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| Description | |
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| Overview | A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. |
| Catalogue Number | 330005 |
| Brand Family | Calbiochem® |
| Synonyms | Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d |
| Product Information | |
|---|---|
| CAS number | 88321-09-9 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₁₇H₃₀N₂O₅ |
| Chemical formula | C₁₇H₃₀N₂O₅ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | calpain-1 |
| Primary Target IC<sub>50</sub> | 10-100 µM for calpain-1 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Safety Information according to GHS | |
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| RTECS | RR0404300 |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 330005-1MGCN | 04055977195699 |
Documentation
EST - CAS 88321-09-9 - Calbiochem (M)SDS
| タイトル |
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EST - CAS 88321-09-9 - Calbiochem 試験成績書（CoA）
| タイトル | ロット番号 |
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| 330005 |
参考資料
| 参考資料の概要 |
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| Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129. Mehdi, S. 1991. Trends Biochem. Sci. 16, 150. McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432. Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678. Komatsu, K., et al. 1986. Exp. Neurol. 91, 23. Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672. |
引用
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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