Millipore Sigma Vibrant Logo

324630 EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem

The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and adenosine deaminase.

EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl

Primary Target: PDE 2
View This Product on Sigma-Aldrich
324630
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
51350-19-7C₁₄H₂₃N₅O · HCl

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
324630-10MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 10 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
      Catalogue Number324630
      Brand Family Calbiochem®
      Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
      References
      ReferencesBurton, P., et al. 2010. Biochem. J. in press.
      Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
      Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
      Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
      Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
      Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
      Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
      Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
      Product Information
      CAS number51350-19-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₂₃N₅O · HCl
      Chemical formulaC₁₄H₂₃N₅O · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE 2
      Primary Target IC<sub>50</sub>0.8 and 2 µM against human and procine PDE II, respectively
      Primary Target K<sub>i</sub>4 nM against adenosine deaminase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      324630-10MGCN 04055977196733

      Documentation

      EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      324630

      参考資料

      参考資料の概要
      Burton, P., et al. 2010. Biochem. J. in press.
      Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
      Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
      Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
      Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
      Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
      Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
      Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-February-2012 RFH
      Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
      DescriptionThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
      FormWhite solid
      CAS number51350-19-7
      Chemical formulaC₁₄H₂₃N₅O · HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (25 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBurton, P., et al. 2010. Biochem. J. in press.
      Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
      Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
      Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
      Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
      Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
      Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
      Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.