数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

324832 Sigma-AldrichEGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem

The EGFR Inhibitor II, BIBX1382, also referenced under CAS 196612-93-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: N⁸-(3-Chloro-4-fluorophenyl)-N²-(1-methylpiperidin-4-yl)-pyrimido[5,4-d]pyrimidine-2,8-diamine, 2HCl, BIBX1382BS

Primary Target: EGFR (ErbB-1, HER-1)

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
196612-93-8	C₁₈H₁₉ClFN₇ • 2HCl • 2H₂O

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
324832-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable pyrimidopyrimidine compound that acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of EGFR (ErbB-1, HER-1) both in cell-free enzymatic reactions (IC₅₀ = 3 nM) and in culture (IC₅₀ = 0.15, 1.82, and 3.2 µM in EGF-, HGF-, and FCS-dependent thymidine incorporation, respectively, in KB cells). It exhibits 1,000-fold greater selectivity over ErbB-2 (HER-2, neu; IC₅₀ = 3.4 µM) and shows little activity towards IGF1R, β-InsRK, HGFR, c-src, and VEGFR-2 even at concentrations as high as 10 µM. Its antitumor efficacy has also been demonstrated in a murine xenograft model in vivo (10 mg/kg, daily, p.o.).
Catalogue Number	324832
Brand Family	Calbiochem®
Synonyms	N⁸-(3-Chloro-4-fluorophenyl)-N²-(1-methylpiperidin-4-yl)-pyrimido[5,4-d]pyrimidine-2,8-diamine, 2HCl, BIBX1382BS

References
References	Solca, F.F., et al. 2004. J. Pharm. Exp. Ther. 311, 502. Egeblad, M., et al. 2001. Biochem. Biophys. Res. Commun. 281, 25. Nuijen, B., et al. 2000. Int. J. Pharm. 194, 261.

Product Information
CAS number	196612-93-8
ATP Competitive	Y
Form	Yellow solid
Hill Formula	C₁₈H₁₉ClFN₇ • 2HCl • 2H₂O
Chemical formula	C₁₈H₁₉ClFN₇ • 2HCl • 2H₂O
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application Comments	Tocris suggests 50 mM solution can be made in water or DMSO. Aliquot & store at -20*C; stable for 6 months.

Biological Information
Primary Target	EGFR (ErbB-1, HER-1)
Primary Target IC<sub>50</sub>	3 nM against EGFR (ErbB-1, HER-1) in cell-free enzymatic reactions; 0.15, 1.82, and 3.2 µM in EGF-, HGF-, and FCS-dependent thymidine incorporation, respectively, in KB cells
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
324832-5MGCN	04055977215717

Documentation

EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
324832	ロット番号を入力

参考資料

参考資料の概要
Solca, F.F., et al. 2004. J. Pharm. Exp. Ther. 311, 502. Egeblad, M., et al. 2001. Biochem. Biophys. Res. Commun. 281, 25. Nuijen, B., et al. 2000. Int. J. Pharm. 194, 261.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-April-2011 JSW
Synonyms	N⁸-(3-Chloro-4-fluorophenyl)-N²-(1-methylpiperidin-4-yl)-pyrimido[5,4-d]pyrimidine-2,8-diamine, 2HCl, BIBX1382BS
Description	A cell-permeable pyrimidopyrimidine compound that acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of EGFR (ErbB-1, HER-1) both in cell-free enzymatic reactions (IC₅₀ = 3 nM) and in culture (IC₅₀ = 0.15, 1.82, and 3.2 µM in EGF-, HGF-, and FCS-dependent thymidine incorporation, respectively, in KB cells). It exhibits 1,000-fold greater selectivity over ErbB-2 (HER-2, neu; IC₅₀ = 3.4 µM) and shows little activity towards IGF1R, β-InsRK, HGFR, c-src, and VEGFR-2 even at concentrations as high as 10 µM. Its antitumor efficacy has also been demonstrated in a murine xenograft model in vivo (daily p.o. dose 10 mg/kg).
Form	Yellow solid
CAS number	196612-93-8
Chemical formula	C₁₈H₁₉ClFN₇ • 2HCl • 2H₂O
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (25 mg/ml) or H₂O (1 mg/ml)
Comments	Tocris suggests 50 mM solution can be made in water or DMSO. Aliquot & store at -20*C; stable for 6 months.
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Solca, F.F., et al. 2004. J. Pharm. Exp. Ther. 311, 502. Egeblad, M., et al. 2001. Biochem. Biophys. Res. Commun. 281, 25. Nuijen, B., et al. 2000. Int. J. Pharm. 194, 261.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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