Millipore Sigma Vibrant Logo

322338 Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem

The Dvl-PDZ Domain Inhibitor II, also referenced under CAS 294891-81-9, controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor IV

View This Product on Sigma-Aldrich
322338
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
294891-81-9C₂₂H₁₈N₂O₄

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
322338-10MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
      Catalogue Number322338
      Brand Family Calbiochem®
      Synonyms2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor IV
      References
      ReferencesGrandy, D., et al. 2009. J. Biol. Chem. 284, 16256.
      Product Information
      CAS number294891-81-9
      FormWhite solid
      Hill FormulaC₂₂H₁₈N₂O₄
      Chemical formulaC₂₂H₁₈N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      322338-10MGCN 04055977216356

      Documentation

      Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      322338

      参考資料

      参考資料の概要
      Grandy, D., et al. 2009. J. Biol. Chem. 284, 16256.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2011 RFH
      Synonyms2-((3-(2-Phenylacetyl)amino)benzoyl)amino)benzoic acid, 3289-8625, Wnt Pathway Inhibitor IV
      DescriptionA cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 µM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 µM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 µM; IC50 = 12.5 µM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 µM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number294891-81-9
      Chemical formulaC₂₂H₁₈N₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrandy, D., et al. 2009. J. Biol. Chem. 284, 16256.