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309866 Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem

Synthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist.

Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: L-Type Calcium Channel Blocker II

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309866
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概要

Replacement Information

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309866-100MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 100 mg
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      Description
      OverviewSynthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.
      Catalogue Number309866
      Brand Family Calbiochem®
      SynonymsL-Type Calcium Channel Blocker II
      References
      Referencesvan Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
      Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
      Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
      Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2792.
      Gallizzi, J.P., et al. 1986. J. Biol. Chem. 261, 1393.
      Garcia, M.L., et al. 1986. J. Biol. Chem. 261, 8146.
      Product Information
      CAS number33286-22-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₂₆N₂O₄S · HCl
      Chemical formulaC₂₂H₂₆N₂O₄S · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetL-type Ca2+ channel
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDL0310000
      Safety Information
      R PhraseR: 22-40

      Harmful if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      309866-100MGCN 04055977216820

      Documentation

      Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      309866

      参考資料

      参考資料の概要
      van Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
      Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
      Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
      Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2792.
      Gallizzi, J.P., et al. 1986. J. Biol. Chem. 261, 1393.
      Garcia, M.L., et al. 1986. J. Biol. Chem. 261, 8146.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2008 RFH
      SynonymsL-Type Calcium Channel Blocker II
      DescriptionSynthetic (+)-cis isomer that acts as an L-type Ca2+ channel antagonist. Similar in function to nifedipine and verapamil. Has a negative inotropic effect on the heart. Strongly suppresses conductance at the A-V node and automatically at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.
      FormWhite solid
      CAS number33286-22-5
      RTECSDL0310000
      Chemical formulaC₂₂H₂₆N₂O₄S · HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml), Methanol, or chloroform
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 3202
      Referencesvan Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
      Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
      Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
      Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2792.
      Gallizzi, J.P., et al. 1986. J. Biol. Chem. 261, 1393.
      Garcia, M.L., et al. 1986. J. Biol. Chem. 261, 8146.