Millipore Sigma Vibrant Logo

GF170 DKK-1 Protein, Human Recombinant

The Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy.

DKK-1 Protein, Human Recombinant: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
UniProt Number: O94907
View This Product on Sigma-Aldrich
GF170
10 µg  
価格を検索中…
価格が見つかりません
Minimum Quantity needs to be mulitiple of
Maximum Quantity is
弊社照会 詳細を表示　
値引
()
 
—
弊社照会
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

       

      お問合せください

      概要

      Replacement Information

      主要スペック表

      SourcePurity
      HEK293 CellsProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses
      Description
      Catalogue NumberGF170
      DescriptionDKK-1 Protein, Human Recombinant
      Alternate Names
      • Dickkopf related protein 1
      • DKK1
      • DKK
      • SK
      Background InformationDickkopf related protein 1 (Dkk1) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4, and a related protein, Soggy. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.
      References
      Product Information
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      ApplicationThe Dickkopf related protein 1 (or Dkk1 protein) is the founding member of the Dickkopf family of proteins that includes Dkk1, 2, 3, 4 & a related protein, Soggy.
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 97% pure by SDS-PAGE gel and HPLC analyses
      SourceHEK293 Cells
      Cross ReactivityNone
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200ng/ml.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      GF170 04053252691355

      Documentation

      DKK-1 Protein, Human Recombinant (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      DKK-1 Protein, Human Recombinant 試験成績書（CoA）

      タイトルロット番号
      Recombinant Human -2573001 2573001
      Recombinant Human -2604334 2604334
      Recombinant Human DKK-1 2458038
      Recombinant Human DKK-1 - 2039816 2039816
      Recombinant Human DKK-1 - 2092740 2092740
      Recombinant Human DKK-1 - 2219399 2219399
      Recombinant Human DKK-1 - 2314807 2314807
      Recombinant Human DKK-1 - 3068557 3068557
      Recombinant Human DKK-1 - 3428775 3428775
      Recombinant Human DKK-1 - 3552759 3552759
      Show more

      カタログ

      タイトル
      New Products: Volume 3, 2012

      関連製品＆アプリケーション

      製品ファミリー

      サイトカインおよび成長因子

      メルクミリポアは、細胞培養、幹細胞分化誘導あるいはELISA実験用に、高純度かつ高活性のヒト、マウスおよびラットのサイトカインや成長因子を幅広く提供しています。
      詳細はこちら >>

      カテゴリー

      Life Science Research > タンパク質と酵素 > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors