化合物創出/ HTS
Drug discovery groups that once tested hundreds of novel chemical entities (NCEs) per screen now process thousands daily.
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Drug discovery groups that once tested hundreds of novel chemical entities (NCEs) per screen now process thousands daily. 表示を少なく
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概要
仕様
ご注文情報
Documentation
FAQ（よくある質問と回答）
| 質問 | 回答 |
|---|---|
| Do the harvest plates replace the MultiScreen MAFB and MAFC plates? | 1. No. The design of Harvest plates do not allow for the collection of filtrate or incubation. For assay development, or for any assay where incubation in the filtration plate or where filtrate collection is required must be done in the MultiScreen assay plates. 2. These plates are available with glass fiber filters only. Assays requiring different filter matrices must be done in MultiScreen assay plates. |
| How do I seal the wells of a MultiScreen Harvest plate prior to analysis in a 96 well scintillation counter? | 1. Seal the bottom of the wells with scintillant -resistant tape (opaque for top reading instruments, Cat. # MATAH0P00; clear for bottom reading or coincidence counting, Cat. # MATAHCL00). 2. Add scintillant to the wells. 3. Seal the top of the plate with clear tape, Cat. # MATAHCL00. 4. Count. |
関連製品＆アプリケーション
関連製品: Application Facete
| Sample Preparation |
| Dialysis and Filtration |
関連製品: Brand Facete
| MultiScreen™ |
カテゴリー
| Life Science Research > Cell Culture and Systems > Cell Culture Flasks, Plates, & Slides > Multiwell Plates |
かつて1スクリーン当たり数百のnovel chemical entities (NCEs)を試験していた創薬グループは、今日では日に数千の処理をしています。このスループットの増加は、大部分はコンビナトリアルケミストリー合成などのリード化合物創出法における進歩によるものです。この技術を使用し、研究者は大きな化合物ライブラリーを迅速につくることができ、その後に疾病標的との相互作用に関して探索されます。
ビーズ開裂プロトコール
)
| 1. | 合成ビーズを適切な反応容器に入れる |
| 2. | 反応原系を添加; シール; 反応 |
| 3. | ビーズをマルチスクリーンフィルタープレートに移す; 開裂試薬を添加; インキュベート |
| 4. | 薬剤合成物をレシーバープレート中にろ過し、ビーズをマルチスクリーンプレート中に回収 |
マルチスクリーン レジストプレート
All MultiScreen Solvinert plate materials are selected for broad chemical compatibility and enable extended in-plate incubations with no leaking. The one-piece plate designs incorporate rigid sidewalls to facilitate use with robotic gripper arms and provide space for barcode labels.
They are available with chemically-resistant hydrophilic and hydrophobic membranes to accommodate aqueous and non-aqueous samples. Both membranes are highly retentive (>99% retention of acid precipitated BSA).
For the broadest chemical resistance, hydrophobic PTFE membrane is recommended. Designed for extended sample incubation times and the lowest extractables, hydrophobic PTFE membrane is ideal for NCE cleavage and cleanup, as well as peptide synthesis. They are also suitable for sample recovery following in-plate compound cleavage from solids or beads.
Hydrophilic PTFE membrane is optimized for low drug and protein binding with excellent throughput in typical aqueous and solvent sample preparation. High sample recoveries and low extractables provide for optimum analysis by HPLC and LC-MS/MS.