数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

238803 Sigma-AldrichCdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

The Cdk2 Inhibitor III, also referenced under CAS 199986-75-9, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: 2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313

Primary Target: Cdk2/A, Cdk2/E

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
199986-75-9	C₂₀H₂₈N₆O₃

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
238803-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
238803-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC₅₀ = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC₅₀ > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC₅₀ = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
Catalogue Number	238803
Brand Family	Calbiochem®
Synonyms	2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313

References
References	Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417. Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.

Product Information
CAS number	199986-75-9
ATP Competitive	Y
Declaration	Sold under license of U.S. Patents 6,617,331 and 6,803,371.
Form	White to off-white solid
Hill Formula	C₂₀H₂₈N₆O₃
Chemical formula	C₂₀H₂₈N₆O₃
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Cdk2/A, Cdk2/E
Primary Target IC<sub>50</sub>	0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
238803-1MGCN	04055977216608
238803-5MGCN	04055977216615

Documentation

Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
238803	ロット番号を入力

参考資料

参考資料の概要
Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417. Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-October-2020 JSW
Synonyms	2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
Description	A cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC₅₀ = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC₅₀ > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC₅₀ ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
Form	White to off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	199986-75-9
Chemical formula	C₂₀H₂₈N₆O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417. Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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