数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

219401 Sigma-AldrichCathepsin D, Human Liver

Cathepsin D, Human Liver, CAS 9025-26-7, is a purified native cathepsin D from human liver. Overexpression of cathepsin D in is associated with higher risk of cancer relapse and metastasis.

Cathepsin D, Human Liver: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

試験成績書（CoA）
参考資料
カタログ
Data Sheet

お勧めの製品

概要

Replacement Information

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
219401-15UCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	15 u	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
219401-30UCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	30 u	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	Native cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
Catalogue Number	219401
Brand Family	Calbiochem®

References
References	Berchem, G., et al. 2002. Oncogene 21, 5951. Barbi, G.P., et al. 1994. Oncology 51, 329. Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586. Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577. Erickson, A. 1989. J. Cell. Biochem. 40, 31.

Product Information
CAS number	9025-26-7
Unit of Definition	One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
EC number	3.4.23.5
Form	Lyophilized
Formulation	Lyophilized from 2 mM sodium phosphate buffer, pH 6.5.
Quality Level	MQ100

Applications

Biological Information
Purity	≥90% by SDS-PAGE
Source	Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity	≥300 units/mg protein

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
219401-15UCN	04055977201710
219401-30UCN	04055977201727

Documentation

Cathepsin D, Human Liver 試験成績書（CoA）

タイトル	ロット番号
219401	ロット番号を入力

参考資料

参考資料の概要
Berchem, G., et al. 2002. Oncogene 21, 5951. Barbi, G.P., et al. 1994. Oncology 51, 329. Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586. Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577. Erickson, A. 1989. J. Cell. Biochem. 40, 31.

カタログ

タイトル
Cathepsins and Related Products Technical Bulletin

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-April-2008 RFH
Description	Native cathepsin D from human liver. Degrades the extracellular matrix and releases growth factors bound to the matrix. Overexpression of cathepsin D in human breast cancers is associated with a higher risk of relapse and metastasis.
Form	Lyophilized
Formulation	Lyophilized from 2 mM sodium phosphate buffer, pH 6.5.
Source	Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number	9025-26-7
EC number	3.4.23.5
Purity	≥90% by SDS-PAGE
Specific activity	≥300 units/mg protein
Unit definition	One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
Solubility	Sterile H₂O or aqueous buffers. Please see vial label for lot-specific reconstitution volume.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
Toxicity	Standard Handling
Merck USA index	14, 1905
References	Berchem, G., et al. 2002. Oncogene 21, 5951. Barbi, G.P., et al. 1994. Oncology 51, 329. Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586. Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577. Erickson, A. 1989. J. Cell. Biochem. 40, 31.

カテゴリー

Life Science Research > タンパク質と酵素 > Other Enzymes

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