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219385 Cathepsin B Inhibitor II - Calbiochem

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219385
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概要

Replacement Information

主要スペック表

Empirical Formula
C₁₉H₃₆N₄O₄

価格&在庫状況

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219385-1MGCN
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      樹脂アンプル 1 mg
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      Description
      OverviewA more active lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) compared to leupeptin (IC50 = 310 nM).
      Note: this peptide forms cyclic isomers.
      Catalogue Number219385
      Brand Family Calbiochem®
      SynonymsAc-LVK-CHO
      References
      ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₉H₃₆N₄O₄
      Chemical formulaC₁₉H₃₆N₄O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin B
      Primary Target IC<sub>50</sub>4 nM against cathepsin B
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Leu-Val-lysinal
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      219385-1MGCN 04055977201666

      Documentation

      Cathepsin B Inhibitor II - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Cathepsin B Inhibitor II - Calbiochem 試験成績書(CoA)

      タイトルロット番号
      219385

      参考資料

      参考資料の概要
      McConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.

      カタログ

      タイトル
      Cathepsins and Related Products Technical Bulletin

      引用

      Title
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
    • データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      SynonymsAc-LVK-CHO
      DescriptionLysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) than of leupeptin (IC50 = 310 nM). Note: this peptide forms cyclic isomers.
      FormWhite solid
      Chemical formulaC₁₉H₃₆N₄O₄
      Peptide SequenceAc-Leu-Val-lysinal
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Toxicity Standard Handling
      ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
      Citation
    • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.