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219007 Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem

Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.

Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Z-VAD-FMK

Primary Target: general caspase inhibitor
View This Product on Sigma-Aldrich
219007
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
161401-82-7C₂₁H₂₈FN₃O₇

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
219007-1MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 mg
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      219007-250UGCN
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          		 樹脂ｱﾝﾌﾟﾙ 250 μg
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          Description
          OverviewAn irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.
          Catalogue Number219007
          Brand Family Calbiochem®
          SynonymsZ-VAD-FMK
          References
          ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
          Product Information
          CAS number161401-82-7
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₁H₂₈FN₃O₇
          Chemical formulaC₂₁H₂₈FN₃O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetgeneral caspase inhibitor
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceZ-Val-Ala-Asp-CH₂F*
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          219007-1MGCN 07790788048648
          219007-250UGCN 04055977202021

          Documentation

          Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          219007

          参考資料

          参考資料の概要
          Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.

          カタログ

          タイトル
          Caspases and other Apoptosis Related Tools Brochure

          引用

          Title
        • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
        • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
        • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
        • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
        • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.
          		•
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2014 JSW
          SynonymsZ-VAD-FMK
          DescriptionA cell-permeable, irreversible, and general caspase inhibitor. Also reported to inhibit Peptide: N-glycanase (PNGase) in vitro and in vivo. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies.
          FormOff-white solid
          CAS number161401-82-7
          Chemical formulaC₂₁H₂₈FN₃O₇
          Peptide SequenceZ-Val-Ala-Asp-CH₂F*
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (9 mg/ml)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
          Citation
        • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
        • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
        • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
        • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
        • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.
          		•