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215900 Carbonic Anhydrase IX/XII Inhibitor - CAS 175014-68-3 - Calbiochem

The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

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同義語: CAIX Inhibitor

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215900
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
175014-68-3C₁₃H₁₂N₄O₅S

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      		 ｶﾞﾗｽﾋﾞﾝ 5 mg
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      Description
      OverviewA cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (Ki = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.
      Catalogue Number215900
      Brand Family Calbiochem®
      SynonymsCAIX Inhibitor
      References
      ReferencesPacchiano, F., et al. 2011. J Med Chem. 54, 1896.
      Product Information
      CAS number175014-68-3
      FormWhite solid
      Hill FormulaC₁₃H₁₂N₄O₅S
      Chemical formulaC₁₃H₁₂N₄O₅S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      215900-5MGCN 04055977219210

      Documentation

      Carbonic Anhydrase IX/XII Inhibitor - CAS 175014-68-3 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Carbonic Anhydrase IX/XII Inhibitor - CAS 175014-68-3 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      215900

      参考資料

      参考資料の概要
      Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-April-2012 JSW
      SynonymsCAIX Inhibitor
      DescriptionA cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (Ki = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number175014-68-3
      Chemical formulaC₁₃H₁₂N₄O₅S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesPacchiano, F., et al. 2011. J Med Chem. 54, 1896.