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390238 Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem

A cell-permeable powerful DNA topoisomerase I inhibitor.

Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 10-Hydroxycamptothecin, HCPT

Primary Target: DNA topoisomerase I
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390238
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
64439-81-2C₂₀H₁₆N₂O₅

価格＆在庫状況

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390238-25MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 25 mg
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      Description
      OverviewA cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
      Catalogue Number390238
      Brand Family Calbiochem®
      Synonyms10-Hydroxycamptothecin, HCPT
      References
      ReferencesZhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
      Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
      Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.
      Product Information
      CAS number64439-81-2
      ATP CompetitiveN
      FormPale yellow powder
      Hill FormulaC₂₀H₁₆N₂O₅
      Chemical formulaC₂₀H₁₆N₂O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA topoisomerase I
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      390238-25MGCN 04055977189988

      Documentation

      Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      390238

      参考資料

      参考資料の概要
      Zhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
      Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
      Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      Synonyms10-Hydroxycamptothecin, HCPT
      DescriptionA cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.
      FormPale yellow powder
      CAS number64439-81-2
      Chemical formulaC₂₀H₁₆N₂O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesZhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
      Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
      Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.