数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

03-34-0051 Sigma-AldrichCalpeptin - CAS 117591-20-5 - Calbiochem

Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Calpeptin - CAS 117591-20-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet
Citations

同義語: Benzyloxycarbonylleucyl-norleucinal

Primary Target: Calpain-1

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
117591-20-5	C₂₀H₃₀N₂O₄

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
03-34-0051-100MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	100 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
03-34-0051-25MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	25 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
03-34-0051-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable calpain inhibitor (ID₅₀ = 52 nM for calpain-1; ID₅₀ = 34 nM for calpain-2; ID₅₀ = 138 nM for papain). Inhibits the Ca²⁺-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca²⁺-ionophore-induced degradation of actin binding protein and P₂₃₅ in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Catalogue Number	03-34-0051
Brand Family	Calbiochem®
Synonyms	Benzyloxycarbonylleucyl-norleucinal

References
References	Lee, M.S., et al. 2000. Nature 405, 360. Yamazaki, T., et al. 1997. Biochemistry 27, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

References

Lee, M.S., et al. 2000. Nature 405, 360.
Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Shiba, E., et al. 1996. Anticancer Res. 16, 773.
Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

Product Information
CAS number	117591-20-5
ATP Competitive	N
Form	White to off-white solid
Hill Formula	C₂₀H₃₀N₂O₄
Chemical formula	C₂₀H₃₀N₂O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Biological Information
Primary Target	Calpain-1
Primary Target IC<sub>50</sub>	ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Leu-Nle-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
03-34-0051-100MGCN	04055977206838
03-34-0051-25MGCN	04055977206845
03-34-0051-5MGCN	04055977206852

Documentation

Calpeptin - CAS 117591-20-5 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Calpeptin - CAS 117591-20-5 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
03-34-0051	ロット番号を入力

参考資料

参考資料の概要
Lee, M.S., et al. 2000. Nature 405, 360. Yamazaki, T., et al. 1997. Biochemistry 27, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

参考資料の概要

引用

Title

Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.

Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-October-2007 JSW
Synonyms	Benzyloxycarbonylleucyl-norleucinal
Description	A cell-permeable calpain inhibitor. Inactivates calpain I (ID₅₀ = 52 nM), calpain II (ID₅₀ = 34 nM), and papain (ID₅₀ = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca²⁺-ionophore induced degradation of actin binding protein and P₂₃₅ in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Form	White to off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	117591-20-5
Chemical formula	C₂₀H₃₀N₂O₄
Peptide Sequence	Z-Leu-Nle-CHO
Structure formula
Purity	≥94% by HPLC
Solubility	DMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity	Standard Handling
References	Lee, M.S., et al. 2000. Nature 405, 360. Yamazaki, T., et al. 1997. Biochemistry 27, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
Citation	Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879. Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors

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