数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

208745 Sigma-AldrichCalpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
カタログ
Data Sheet

同義語: N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017

Primary Target: µ-calpain

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
190274-53-4	C₁₇H₂₅FN₂O₄S

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
208745-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
208745-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A potent, cell-permeable, reversible inhibitor of calpain (IC₅₀ = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC₅₀ = 15 nM) and L (IC₅₀ = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
Catalogue Number	208745
Brand Family	Calbiochem®
Synonyms	N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017

References
References	Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

References

Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

Product Information
CAS number	190274-53-4
ATP Competitive	N
Declaration	Sold under license of U.S. Patent 6,551,999
Form	White lyophilized solid
Hill Formula	C₁₇H₂₅FN₂O₄S
Chemical formula	C₁₇H₂₅FN₂O₄S
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	µ-calpain
Primary Target IC<sub>50</sub>	7.5 nM for µ-calpain and 78 nM for m-calpain; 15 nM and 1.6 nM against cathepsin B and L, respectively
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	4-Fluorophenylsulfonyl-Val-Leu-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
208745-1MGCN	04055977202816
208745-5MGCN	04055977202823

Documentation

Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
208745	ロット番号を入力

参考資料

参考資料の概要
Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

参考資料の概要

カタログ

タイトル
Caspases and other Apoptosis Related Tools Brochure

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-February-2014 JSW
Synonyms	N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
Description	A cell-permeable peptide aldehyde that acts as a potent and reversible inhibitor of calpain (IC₅₀ = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC₅₀ = 15 nM) and cathepsin L (IC₅₀ = 1.6 nM). Reduces βFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation in rats. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured rat lenses.
Form	White lyophilized solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	190274-53-4
Chemical formula	C₁₇H₂₅FN₂O₄S
Peptide Sequence	4-Fluorophenylsulfonyl-Val-Leu-CHO
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors

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