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208724 Calpain Inhibitor IV - Calbiochem

Calpain Inhibitor IV, Z-LLY-FMK, CAS 133410-84-1, is a cell-permeable, potent, irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also blocks cathepsin L activity (k2 = 680,000 M-1s-1).

Calpain Inhibitor IV - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Z-LLY-FMK

Primary Target: calpain 2
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208724
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

Empirical Formula
C₃₀H₄₀FN₃O₆

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
208724-1MGCN
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      Description
      OverviewA potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
      Catalogue Number208724
      Brand Family Calbiochem®
      SynonymsZ-LLY-FMK
      References
      ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
      Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
      Product Information
      ATP CompetitiveN
      FormWhite to pale yellow solid
      Hill FormulaC₃₀H₄₀FN₃O₆
      Chemical formulaC₃₀H₄₀FN₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCalpain Inhibitor IV, Z-LLY-FMK, CAS 133410-84-1, is a cell-permeable, potent, irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also blocks cathepsin L activity (k2 = 680,000 M-1s-1).
      Biological Information
      Primary Targetcalpain 2
      Primary Target IC<sub>50</sub>k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L
      Puritysingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      208724-1MGCN 04055977202694

      Documentation

      Calpain Inhibitor IV - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Calpain Inhibitor IV - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      208724

      参考資料

      参考資料の概要
      Dutt, P., et al. 1998. FEBS Lett. 436, 367.
      Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

      カタログ

      タイトル
      Caspases and other Apoptosis Related Tools Brochure

      引用

      Title
    • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
      		•
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2013 JSW
      SynonymsZ-LLY-FMK
      DescriptionA potent, cell-permeable and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).
      FormWhite to pale yellow solid
      Chemical formulaC₃₀H₄₀FN₃O₆
      Peptide SequenceZ-Leu-Leu-Tyr-CH₂F
      Structure formulaStructure formula
      Puritysingle spot by TLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDutt, P., et al. 1998. FEBS Lett. 436, 367.
      Angliker, H., et al. 1992. J. Med. Chem. 35, 216.
      Citation
    • Georg Rosenberger, Andreas Gal and Kerstin Kutsche. (2005) αPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading. Journal of Biological Chemistry (280) 6879-6889.
      		•

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      カテゴリー

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors