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208722 Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

Calpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).

Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Carbobenzoxy-valinyl-phenylalaninal, MDL 28170

Primary Target: calpain 1, calpain 2
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208722
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
88191-84-8C₂₂H₂₆N₂O₄

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
208722-25MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 25 mg
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      Description
      OverviewA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.
      Catalogue Number208722
      Brand Family Calbiochem®
      SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
      References
      ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
      Rami, A., et al. 1997. Neurosci. Res. 27, 93.
      Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Chard, P.S., et al. 1995. Neuroscience 65, 1099.
      Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
      Product Information
      CAS number88191-84-8
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₂H₂₆N₂O₄
      Chemical formulaC₂₂H₂₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCalpain Inhibitor III, CAS 88191-84-8, is a potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM).
      Biological Information
      Primary Targetcalpain 1, calpain 2
      Primary Target IC<sub>50</sub>8 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Val-Phe-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      208722-25MGCN 04055977202687

      Documentation

      Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      208722

      参考資料

      参考資料の概要
      Chatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
      Rami, A., et al. 1997. Neurosci. Res. 27, 93.
      Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Chard, P.S., et al. 1995. Neuroscience 65, 1099.
      Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

      カタログ

      タイトル
      Caspases and other Apoptosis Related Tools Brochure

      引用

      Title
    • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
    • Dong, Y., et al. 2006. FASEB Journal in press,.
    • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
    • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
      		•
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCarbobenzoxy-valinyl-phenylalaninal, MDL 28170
      DescriptionA potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
      FormWhite lyophilized solid
      CAS number88191-84-8
      Chemical formulaC₂₂H₂₆N₂O₄
      Peptide SequenceZ-Val-Phe-CHO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml). Use only anhydrous DMSO.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesChatterjee, S., et al. 1998. J. Med. Chem. 41, 2663.
      Rami, A., et al. 1997. Neurosci. Res. 27, 93.
      Yamazaki, T., et al. 1997. Biochemistry 36, 8377.
      Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
      Chard, P.S., et al. 1995. Neuroscience 65, 1099.
      Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.
      Citation
    • Dong, Y., et al. 2009. J. Cell Mol. Med. 13, 2899.
    • Dong, Y., et al. 2006. FASEB Journal in press,.
    • So-Young Park and Adriana Ferreira. 2005. Journal of Neuroscience 25, 5365.
    • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
      		•

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      カテゴリー

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors