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236015 COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem

The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide

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236015
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
116686-15-8C₁₅H₁₃F₂NO₄S

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      		 ｶﾞﾗｽﾋﾞﾝ 5 mg
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      Description
      OverviewA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
      Catalogue Number236015
      Brand Family Calbiochem®
      Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
      References
      ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
      Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
      Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
      Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
      Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
      Product Information
      CAS number116686-15-8
      FormWhite solid
      Hill FormulaC₁₅H₁₃F₂NO₄S
      Chemical formulaC₁₅H₁₃F₂NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      236015-5MGCN 04055977217155

      Documentation

      COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      236015

      参考資料

      参考資料の概要
      Otani, Y., et al. 2007. J. Invest. Surg. 20, 175.
      Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
      Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
      Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
      Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2009 RFH
      Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
      DescriptionA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number116686-15-8
      Chemical formulaC₁₅H₁₃F₂NO₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
      Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
      Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
      Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
      Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.