数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

236005 Sigma-AldrichCOX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

Primary Target: COX-1, COX-2

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
130717-51-0	C₂₃H₂₅N₃O₃S • HCl

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
236005-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1 (IC₅₀ = 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively). Displays ~2,300 fold greater selectivity towards inhibition of COX-1 over COX-2. Reported to be orally active and display analgesic, anti-platelet and anti-inflammatory properties.
Catalogue Number	236005
Brand Family	Calbiochem®
Synonyms	FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride

References
References	Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782. Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49. Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189. Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.

Product Information
CAS number	130717-51-0
ATP Competitive	N
Form	Pale yellow solid
Hill Formula	C₂₃H₂₅N₃O₃S • HCl
Chemical formula	C₂₃H₂₅N₃O₃S • HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	COX-1, COX-2
Primary Target IC<sub>50</sub>	28 nM and 65 µM for human recombinant COX-1 and COX-2
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
236005-5MGCN	04055977217100

Documentation

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
236005	ロット番号を入力

参考資料

参考資料の概要
Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782. Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49. Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189. Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-June-2008 RFH
Synonyms	FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride
Description	A potent, cell-permeable, and selective inhibitor of COX-1 (IC₅₀ = 28 nM; human recombinant COX-1). Does not significantly inhibit COX-2 (IC₅₀ = 65 µM, human recombinant COX-2). Reported to be orally active and displays analgesic properties in chemical nociceptive animal models. Also reported to exhibit anti-inflammatory effects and suppress prostaglandin E2 and thromboxane 2 levels in collagen-induced arthritis in rats. Shown to be 100 times more potent than aspirin in inhibiting arachidonic acid- and collagen-induced human and guinea pig platelet aggregation.
Form	Pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	130717-51-0
Chemical formula	C₂₃H₂₅N₃O₃S • HCl
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml), H₂O (4 mg/ml), or 1 N HCl (2 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782. Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49. Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189. Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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