数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

233100 Sigma-AldrichCL-387,785 - CAS 194423-06-8 - Calbiochem

A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC₅₀ = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC₅₀ = 5 nM).

CL-387,785 - CAS 194423-06-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785

Primary Target: EGFR kinase activity

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
194423-06-8	C₁₈H₁₃BrN₄O

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
233100-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC₅₀ = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC₅₀ = 5 nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC₅₀ = 31-125 nM) by covalently binding to the EGFR.
Catalogue Number	233100
Brand Family	Calbiochem®
Synonyms	N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785

References
References	Sweeney, W.E., et al. 2000. Kidney Int. 57, 33. Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917. Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.

Product Information
CAS number	194423-06-8
ATP Competitive	N
Form	Pale yellow solid
Hill Formula	C₁₈H₁₃BrN₄O
Chemical formula	C₁₈H₁₃BrN₄O
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	EGFR kinase activity
Primary Target IC<sub>50</sub>	250-490 pM inhibiting EGF-receptor (EGFR) kinase activity in vivo; 5 nM inhibiting EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
233100-1MGCN	04055977217612

Documentation

CL-387,785 - CAS 194423-06-8 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

CL-387,785 - CAS 194423-06-8 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
233100	ロット番号を入力

参考資料

参考資料の概要
Sweeney, W.E., et al. 2000. Kidney Int. 57, 33. Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917. Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-April-2011 RFH
Synonyms	N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785
Description	A cell-permeable and irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC₅₀ = 250-490 pM) and blocks EGF-mediated growth. Also inhibits proliferation of cells that overexpress EGFR or c-Erb-2 (IC₅₀ = 31-125 nM) by covalently binding to EGFR.
Form	Pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	194423-06-8
Chemical formula	C₁₈H₁₃BrN₄O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
References	Sweeney, W.E., et al. 2000. Kidney Int. 57, 33. Discafani, C.M., et al. 1999. Biochem. Pharmacol. 57, 917. Sweeney, W.E., et. al. 1999. Kidney Int. 56, 406.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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