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196870 BAY 11-7082 - CAS 19542-67-7 - Calbiochem

BAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.

BAY 11-7082 - CAS 19542-67-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile

Primary Target: TNF-α-inducible phosphorylation of IκBα
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196870
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
19542-67-7C₁₀H₉NO₂S

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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewPotential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.
      Catalogue Number196870
      Brand Family Calbiochem®
      Synonyms(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
      References
      ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
      Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
      Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
      Product Information
      CAS number19542-67-7
      FormOff-white solid
      Hill FormulaC₁₀H₉NO₂S
      Chemical formulaC₁₀H₉NO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationBAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.
      Biological Information
      Primary TargetTNF-α-inducible phosphorylation of IκBα
      Primary Target IC<sub>50</sub>10 µM inhibiting TNF-α-inducible phosphorylation of IκBα
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      196870-10MGCN 04055977206562

      Documentation

      BAY 11-7082 - CAS 19542-67-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      BAY 11-7082 - CAS 19542-67-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      196870

      参考資料

      参考資料の概要
      Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
      Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
      Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

      カタログ

      タイトル
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

      引用

      Title
    • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
    • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
    • Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295.
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2010 RFH
      Synonyms(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
      DescriptionPotential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number19542-67-7
      Chemical formulaC₁₀H₉NO₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
      Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
      Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
      Citation
    • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
    • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
    • Meng-Hsing Wu, et al. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. 90, 286-295.
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•