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189480 Autocamtide-2 Related Inhibitory Peptide - Calbiochem

The Autocamtide-2 Related Inhibitory Peptide controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Autocamtide-2 Related Inhibitory Peptide - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL

Primary Target: Cam Kinase-2
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189480
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概要

Replacement Information

主要スペック表

Empirical Formula
C₆₄H₁₁₆N₂₂O₁₉

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189480-500UGCN
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      		 樹脂ｱﾝﾌﾟﾙ 500 μg
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      Description
      OverviewNon-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM). It is about 50 times more potent than [Ala286]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca2+-induced insulin secretion from electropermeabilized islets.
      Catalogue Number189480
      Brand Family Calbiochem®
      SynonymsAIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
      References
      ReferencesBhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
      Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₄H₁₁₆N₂₂O₁₉
      Chemical formulaC₆₄H₁₁₆N₂₂O₁₉
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCam Kinase-2
      Primary Target IC<sub>50</sub>40 nM against calmodulin-dependent protein kinase II
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      189480-500UGCN 04055977221770

      Documentation

      Autocamtide-2 Related Inhibitory Peptide - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Autocamtide-2 Related Inhibitory Peptide - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      189480

      参考資料

      参考資料の概要
      Bhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
      Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsAIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
      DescriptionNon-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM) and is 50 and 500 times more potent than Ala286-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₆₄H₁₁₆N₂₂O₁₉
      Peptide SequenceH-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
      Purity≥97% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
      Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.