Millipore Sigma Vibrant Logo

189406 Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

The Aurora Kinase/Cdk Inhibitor, also referenced under CAS 443797-96-4, controls the biological activity of Aurora Kinase/Cdk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621

Primary Target: Aurora Kinase/Cdk
View This Product on Sigma-Aldrich
189406
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
443797-96-4C₁₅H₁₂F₂N₆O₃S • CH₃CN

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
189406-5MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 5 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 - 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
      Catalogue Number189406
      Brand Family Calbiochem®
      Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
      References
      ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
      Lin R., et al. 2005. J. Med. Chem. 48, 4208.
      Product Information
      CAS number443797-96-4
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
      Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAurora Kinase/Cdk
      Primary Target IC<sub>50</sub>11 and 15 nM for Aurora-A, Aurora-B, respectively; 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      189406-5MGCN 04055977221756

      Documentation

      Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      189406

      参考資料

      参考資料の概要
      Emanuel, S., et al. 2005. Cancer Res. 65, 9038.
      Lin R., et al. 2005. J. Med. Chem. 48, 4208.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
      DescriptionA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112-514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number443797-96-4
      Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (15 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
      Lin R., et al. 2005. J. Med. Chem. 48, 4208.