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178494 Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: NS3694

Primary Target: Apoptosome complex formation
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178494
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
426834-38-0C₁₅H₁₀ClF₃N₂O₃

価格＆在庫状況

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178494-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      Description
      OverviewA cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
      Catalogue Number178494
      Brand Family Calbiochem®
      SynonymsNS3694
      References
      ReferencesLademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
      Product Information
      CAS number426834-38-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₀ClF₃N₂O₃
      Chemical formulaC₁₅H₁₀ClF₃N₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetApoptosome complex formation
      Primary Target IC<sub>50</sub>50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      178494-10MGCN 04055977204803

      Documentation

      Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      178494

      参考資料

      参考資料の概要
      Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2009 JSW
      SynonymsNS3694
      DescriptionA cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.
      FormWhite solid
      CAS number426834-38-0
      Chemical formulaC₁₅H₁₀ClF₃N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml). Slightly soluble in ethanol.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.