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04-894 Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal

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04-894
100 µL  
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      概要

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbCulture SupernatantMonoclonal Antibody
      Description
      Catalogue Number04-894
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal
      References
      Product Information
      FormatCulture Supernatant
      PresentationCultured supernantant with 0.05% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W is validated for use in WB for the detection of phospho-KDR/Flk-1/VEGFR2 (Tyr1054).
      Key Applications
      • Western Blotting
      Application NotesWestern Blot: 1:1000-1:4000 dilution for the detection of phospho-KDR/Flk-1/VEGFR2 in RIPA lysates from CSF stimulated porcine aortic endothelial (PAE) cells expressing a human CSF-R1/murine KDR chimeric receptor.
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide encompassing the phosphorylated tyrosine residue 1054 of human KDR/Flk-1/VEGFR2.
      CloneD1W
      HostRabbit
      SpecificityKDR/Flk-1/VEGFR2 phosphorylated on Tyrosine 1054.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NotePredicted to have broad species cross-reactivity based on sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KDR
      • VEGFR-2
      • VEGFR2
      • VEGFR
      • CD309
      • FLK1
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35968 # Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1356 amino acids; 151527 Da
      SUBUNIT: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P35968 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight152 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot in RIPA lysates from CSF stimulated porcine aortic endothelial (PAE) cells expressing a human CSF-R1/murine KDR chimeric receptor.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      04-894 04053252326295

      Documentation

      Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-phospho-KDR/Flk-1/VEGFR2 (Tyr1054) Antibody, clone D1W, rabbit monoclonal 試験成績書(CoA)

      タイトルロット番号
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), -2697398 2697398
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), -2817231 2817231
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), -2820677 2820677
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), clone D1W - 3221100 3221100
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), clone D1W - 3748864 3748864
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), clone D1W - 3842836 3842836
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), clone D1W - 4166552 4166552
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), clone D1W - DAM1528585 DAM1528585
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), clone D1W - JH1774601 JH1774601
      Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054), clone D1W - NG17017 NG17017

      参考資料

      参考資料の概要Pub Med ID
      Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium.
      Dellinger, MT; Brekken, RA
      PloS one  6  e28947  2011

      概要を表示する 記事全文
      22174934 22174934

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies