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ABE26 Anti-acetyl-c-Myc (Lys323) Antibody

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ABE26
100 µg  
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      概要

      Replacement Information

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE26
      DescriptionAnti-acetyl-c-Myc (Lys323) Antibody
      Alternate Names
      • Myc proto-oncogene protein
      • Class E basic helix-loop-helix protein 39
      • HLHe39
      • Proto-oncogene c-Myc
      • Transcription factor p64
      • c-MYC
      Background Informationc-Myc (bHLHe39) is a transcription factor that regulates the expression of multiple genes involved in apoptosis, cell growth, differentiation, and proliferation. Active c-Myc is coupled to the MAX protein via c-Myc’s C-terminal helix-loop-helix leucine zipper (bHLHLZ) domain. The c-Myc-MAX heterodimer also interacts with a number of other transcription-related proteins including TRRAP, p107 and Miz-1, and c-Myc-MAX may indirectly regulate histone acetylases involved in chromatin remodeling. c-Myc is itself acetylated on lysine 323 by GCN5, and on lysine 148 and 157 by p300/CBP. The significance of c-Myc acetylation is still under investigation; however, previous studies have suggested that HAT-dependent acetylation of c-Myc may regulate its turnover and stability. c-Myc may play a role in various cancers such as Burkitt’s lymphoma.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Transfected HEK293T cell lysates
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-acetyl-c-Myc (Lys323) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect acetyl-c-Myc (Lys323) also known as HLHe39, Proto-oncogene c-Myc, Transcription factor p64, c-MYC.
      Key Applications
      • Western Blotting
      Application NotesPeptide Inhibition Assay Analysis: 2 µg/mL from a representative lot blocked acetyl-c-Myc (Lys323) in HEK293T co-transfected with wild type c-Myc or mutant c-Myc (Lys323R) and P300.

      Peptide Inhibition Assay Analysis: A representative lot was used by an independent laboratory in HEK293T cells co-transfected with mouse wildtype c-Myc and P300. (Image courtesy of Dr. Ernest Martinez, Department of Biochemistry, University of California at Riverside.)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human c-Myc acetylated at Lys323.
      EpitopeAcetylated Lys323
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes c-Myc acetylated at Lys323.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human and mouse. Predicted to react with Rhesus Macaque and Chimpanzee based on 100% sequence homology. Other homologies: Rat, Feline, Sheep, and Bovine (90% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MYC
      • BHLHE39
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~58 kDa observed. Uniprot describes two isoforms at 49 and 51 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in transfected HEK293T cell lysates.

      Western Blot Analysis: 0.2 µg/mL of this antibody detected c-Myc on 10 µg of transfected HEK293T cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      ABE26 04053252522178

      Documentation

      Anti-acetyl-c-Myc (Lys323) Antibody (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-acetyl-c-Myc (Lys323) Antibody 試験成績書(CoA)

      タイトルロット番号
      Anti-acetyl-c-Myc (Lys323) - 2379494 2379494
      Anti-acetyl-c-Myc (Lys323) - 2447965 2447965
      Anti-acetyl-c-Myc (Lys323) - 3385843 3385843
      Anti-acetyl-c-Myc (Lys323) - 3604276 3604276
      Anti-acetyl-c-Myc (Lys323) - 3880394 3880394
      Anti-acetyl-c-Myc (Lys323) - 3943330 3943330
      Anti-acetyl-c-Myc (Lys323) - 4090115 4090115
      Anti-acetyl-c-Myc (Lys323) - Q2010835 Q2010835
      Anti-acetyl-c-Myc (Lys323) -2551009 2551009
      Anti-acetyl-c-Myc (Lys323) -2562402 2562402

      参考資料

      参考資料の概要Pub Med ID
      TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells.
      Lynch, JT; Somerville, TD; Spencer, GJ; Huang, X; Somervaille, TC
      Cell death & disease  4  e573  2013

      概要を表示する
      23559008 23559008

      カタログ

      タイトル
      New Products: Volume 3, 2012

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies