数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABC1151 Sigma-AldrichAnti-NY-ESO-1 Antibody, clone D8.38

Detect NY-ESO-1, LAGE-1 using this mouse monoclonal Anti-NY-ESO-1 antibody, clone D8.38, Cat. No. MABC1151. Validated for use in Immunohistochemistry (Paraffin).

Anti-NY-ESO-1 Antibody, clone D8.38: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）

Research Category: Apoptosis & Cancer Gene Symbol: CTAG1A, CTAG, CTAG1, ESO1, LAGE2, LAGE2A, CTAG1B, LAGE2B UniProt Number: P78358, O75638

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MABC1151

100 µL

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概要

Replacement Information

主要スペック表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	IH(P)	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABC1151
Description	Anti-NY-ESO-1 Antibody, clone D8.38
Alternate Names	Cancer/testis antigen 1 Autoimmunogenic cancer/testis antigen NY-ESO-1 Cancer/testis antigen 6.1 CT6.1 L antigen family member 2 LAGE-2
Background Information	Cancer/testis antigen 1 (UniProt: P78358; also known as Autoimmunogenic cancer/testis antigen NY-ESO-1, Cancer/testis antigen 6.1, CT6.1, L antigen family member 2, LAGE-2) is encoded by the CTAG1A (also known as CTAG, CTAG1, ESO1, LAGE2, LAGE2A, CTAG1B, LAGE2B) gene (Gene ID: 1485; 246100) in human. NY-ESO-1 is a human tumor antigen of the cancer/testis family that is highly expressed in many poor-prognosis melanomas and in other cancer types. However, it is not detected in non-malignant tissues with the exception of germ cells and trophoblasts. It contains a C-terminal hydrophobic tail that potentially serves as membrane-associated domain. NY-ESO-1 is expressed from 18 weeks until birth in human fetal testis and in adult testis it is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells. Although the exact function of NY-ESO-1 is still not clear, it has been speculated it might contribute to certain properties, such as immortality, self-renewal, migratory ability, and capacity to invade that favor tumor cell survival. On the basis of its immunogenicity, NY-ESO-1 is considered as one of the most attractive antigens for cancer immunotherapy. T cells engineered to express an affinity-enhanced T cell receptor (TCR) recognizing a naturally processed peptide shared by the cancer-testis antigens NY-ESO-1 and LAGE-1 have been considered as an attractive method for treatment of myeloma and enhance long-term survival of cells.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Detect NY-ESO-1, LAGE-1 using this mouse monoclonal Anti-NY-ESO-1 antibody, clone D8.38, Cat. No. MABC1151. Validated for use in Immunohistochemistry (Paraffin).
Key Applications	Immunohistochemistry (Paraffin)
Application Notes	Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected NY-ESO-1 in human testis tissue. Immunohistochemistry Analysis: A representative lot detected NY-ESO-1 in Immunohistochemistry applications. (Yakirevich, E., et. al. (2003). Clin Cancer Res. 9(17):6453-60; Bujas, T., et. al. (2011). Eur J Histochem. 55(1):e7; Bolli, M., et. al. (2005). Int J Cancer. 115(6):960-6; Groeper, C., et. al. (2007). Int J Cancer. 120(2):337-43).

Biological Information
Immunogen	A full length recombinant human NY-ESO-1 protein.
Epitope	domain of:
Clone	D8.38
Concentration	Please refer to lot specific datasheet.
Host	Mouse
Specificity	Clone D8.38 specifically targets a sequence in the N-terminal region and detects Cancer/testis antigen 1 (NY-ESO1) in human testis
Isotype	IgG1κ
Species Reactivity	Human
Species Reactivity Note	Human.
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_001318.1 NP_758965.2
Gene Symbol	CTAG1A CTAG CTAG1 ESO1 LAGE2 LAGE2A CTAG1B LAGE2B
Purification Method	Protein G purified
UniProt Number	P78358 O75638
Molecular Weight	17.99 kDa calculated.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Immunohistochemistry in human testis tissue. Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected NY-ESO-1 in human testis tissue.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
MABC1151	04054839155963

Documentation

Anti-NY-ESO-1 Antibody, clone D8.38 (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Anti-NY-ESO-1 Antibody, clone D8.38 試験成績書（CoA）

タイトル	ロット番号
Anti-NY-ESO-1, clone D8.38 - 3218986	3218986
Anti-NY-ESO-1, clone D8.38 - 3517400	3517400
Anti-NY-ESO-1, clone D8.38 - 3721246	3721246
Anti-NY-ESO-1, clone D8.38 -Q2809482	Q2809482
Anti-NY-ESO-1, clone D8.38 Monoclonal Antibody	2971793
Anti-NY-ESO-1, clone D8.38 Monoclonal Antibody	3083578

カテゴリー

Life Science Research > Antibodies and Assays > Primary Antibodies

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