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MAB4147 Anti-MRP1 Antibody, clone MRPm5

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MAB4147
100 µg  
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      概要

      Replacement Information

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, WB, IHC, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4147
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MRP1 Antibody, clone MRPm5
      References
      Product Information
      FormatPurified
      PresentationPurified from tissue culture supernatant, serum-free. Liquid containing 0.7% BSA and 0.1% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationDetect MRP1 using this Anti-MRP1 Antibody, clone MRPm5 validated for use in FC, WB, IH, IH(P).
      Key Applications
      • Flow Cytometry
      • Western Blotting
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blotting

      Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections

      Flow Cytometry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenBacterial fusion protein of MRP1 containing amino acids 986-1204 of the protein.
      CloneMRPm5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody reacts with an internal epitope of MRP1, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. The antibody does not cross-react with the human MDR1 and MDR3 gene products.
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
      Gene Symbol
      • ABCC1
      • 4transporter)
      • ABC29
      • GS-X
      • ABCC
      • MRP1
      • DKFZp781G125
      • MRP
      • DKFZp686N04233
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P33527 # May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics (By similarity).
      SIZE: 1531 amino acids; 171561 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Lung, testis and peripheral blood mononuclear cells.
      SIMILARITY: SwissProt: P33527 ## Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      MAB4147 04053252578458

      Documentation

      Anti-MRP1 Antibody, clone MRPm5 (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-MRP1 Antibody, clone MRPm5 試験成績書(CoA)

      タイトルロット番号
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY - 2118044 2118044
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY - 2466968 2466968
      MOUSE ANTI-MRP1 - 4063589 4063589
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY 2925959
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY 3089118
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY - 2090463 2090463
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY - 2159641 2159641
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY - 2224430 2224430
      MOUSE ANTI-MRP1 MONOCLONAL ANTIBODY - 2234177 2234177

      参考資料

      参考資料の概要Pub Med ID
      MGMT Hypermethylation and MDR System in Glioblastoma Cancer Stem Cells.
      Valentina Caldera,Marta Mellai,Laura Annovazzi,Oriana Monzeglio,Angela Piazzi,Davide Schiffer
      Cancer genomics & proteomics  9  2012

      概要を表示する
      22798502 22798502
      Prognostic significance of the immunohistochemical expression of O(6)-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
      Takao Nakagawa, Kazunori Ido, Takahiro Sakuma, Hiroaki Takeuchi, Kazufumi Sato, Toshihiko Kubota, Takao Nakagawa, Kazunori Ido, Takahiro Sakuma, Hiroaki Takeuchi, Kazufumi Sato, Toshihiko Kubota
      Neuropathology : official journal of the Japanese Society of Neuropathology  29  379-88  2009

      概要を表示する
      19019175 19019175
      Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
      Scheffer, G L, et al.
      Cancer Res., 60: 5269-77 (2000)  2000

      概要を表示する
      11016657 11016657
      Tissue distribution of the multidrug resistance protein.
      Flens, M J, et al.
      Am. J. Pathol., 148: 1237-47 (1996)  1996

      概要を表示する
      8644864 8644864
      Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer.
      Nooter, K, et al.
      Ann. Oncol., 7: 75-81 (1996)  1996

      概要を表示する
      9081396 9081396

      データシート

      タイトル
      MOUSE ANTI-MRP1

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies