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AB1936 Anti-Integrin α2 Antibody

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AB1936
100 µL  
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      概要

      Replacement Information

      Special Offers[海外情報]

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ch, H, Ht, M, RELISA, IF, IHC, IP, RIA, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1936
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α2 Antibody
      Alternate Names
      • CD49b
      References
      Product Information
      FormatSerum
      HS Code3002 15 90
      Control
      • Skin (basement membrane), High grade ovarian tumors
      PresentationNeat rabbit antiSerum. Liquid with 0.05% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin α2 Antibody detects level of Integrin α2 & has been published & validated for use in ELISA, IF, IH, IP, RIA & WB.
      Key Applications
      • ELISA
      • Immunofluorescence
      • Immunohistochemistry
      • Immunoprecipitation
      • Radioimmunoassay
      • Western Blotting
      Application NotesImmunofluorescence: 1:500 (suggested for use on acetone-fixed tissue only)

      ELISA/RIA: 1:1000

      Western blot: 1:1000 The antibody has been used to report alpha2 expression in HUVECs during tubule-like structure formation in collagen (Deroanne, 1996). Recognizes ~160kDa alpha 2 subunit

      Immunoprecipitation: 5 μL precipitates alpha2/beta1 from 5 x 106 cells.

      Immunohistochemistry: 1:500

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human alpha2 integrin subunit {KYEKMTKNPDEODETTELSS}
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityHuman alpha2 integrin subunit. Specificity determined by immunoprecipitation from a detergent extract of 35S methionine labeled endothelial cells. The epitope recognized is on the cytoplasmic domain of the protein and is thus intracellular. Shows no cross-reactivity to alpha1, alpha3, alpha4, alpha5, alpha6, or alphaV subunits.
      Species Reactivity
      • Chicken
      • Human
      • Hamster
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
      Gene Symbol
      • ITGA2
      • CD49B
      • VLAA2
      • VLA-2
      • CD49b
      • BR
      • GPIa
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
      SIZE: 1181 amino acids; 129295 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
      SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
      Molecular Weight160kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      AB1936 04053252330384

      Documentation

      Anti-Integrin α2 Antibody (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-Integrin α2 Antibody 試験成績書(CoA)

      タイトルロット番号
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] POLYCLONAL ANTIBODY - 2139993 2139993
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] POLYCLONAL ANTIBODY - 2358846 2358846
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] POLYCLONAL ANTIBODY - 2428473 2428473
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] - 2907614 2907614
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] - 2992838 2992838
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] - 3167108 3167108
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] - 3328238 3328238
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] - 3496547 3496547
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] - 3548394 3548394
      RABBIT ANTI-HUMAN INTEGRIN alpha2 [CD49b] - 3678881 3678881

      参考資料

      参考資料の概要アプリケーション動物種Pub Med ID
      Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of α2β1 integrin and E-cadherin function.
      Bassagañas, S; Carvalho, S; Dias, AM; Pérez-Garay, M; Ortiz, MR; Figueras, J; Reis, CA; Pinho, SS; Peracaula, R
      PloS one  9  e98595  2014

      概要を表示する
      24878505 24878505
      Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity.
      Yao, Y; Chen, ZL; Norris, EH; Strickland, S
      Nature communications  5  3413  2014

      概要を表示する
      Immunohistochemistry24583950 24583950
      OmpA-mediated rickettsial adherence to and invasion of human endothelial cells is dependent upon interaction with α2β1 integrin.
      Hillman, RD; Baktash, YM; Martinez, JJ
      Cellular microbiology  15  727-41  2013

      概要を表示する
      23145974 23145974
      Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway.
      Rintanen, N; Karjalainen, M; Alanko, J; Paavolainen, L; Mäki, A; Nissinen, L; Lehkonen, M; Kallio, K; Cheng, RH; Upla, P; Ivaska, J; Marjomäki, V
      Molecular biology of the cell  23  448-63  2012

      概要を表示する
      22160595 22160595
      A functional genetic screen reveals new regulators of β1-integrin activity.
      Pellinen, T; Rantala, JK; Arjonen, A; Mpindi, JP; Kallioniemi, O; Ivaska, J
      Journal of cell science  125  649-61  2012

      概要を表示する
      22389402 22389402
      Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue.
      Kahle, MP; Lee, B; Pourmohamad, T; Cunningham, A; Su, H; Kim, H; Chen, Y; McCulloch, CE; Barbaro, NM; Lawton, MT; Young, WL; Bix, GJ
      Neuroreport  23  627-30  2012

      概要を表示する
      Western Blotting22643235 22643235
      A new mechanism for pillar formation during tumor-induced intussusceptive angiogenesis: inverse sprouting.
      Paku, S; Dezso, K; Bugyik, E; Tóvári, J; Tímár, J; Nagy, P; Laszlo, V; Klepetko, W; Döme, B
      The American journal of pathology  179  1573-85  2011

      概要を表示する
      21827961 21827961
      Saccharomyces boulardii Improves Intestinal Cell Restitution through Activation of the α2β1 Integrin Collagen Receptor.
      Canonici, Alexandra, et al.
      PLoS ONE, 6: e18427 (2011)  2011

      概要を表示する
      21483797 21483797
      alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells.
      Cailleteau, L; Estrach, S; Thyss, R; Boyer, L; Doye, A; Domange, B; Johnsson, N; Rubinstein, E; Boucheix, C; Ebrahimian, T; Silvestre, JS; Lemichez, E; Meneguzzi, G; Mettouchi, A
      Journal of cell science  123  2491-501  2010

      概要を表示する
      20592186 20592186
      Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas.
      Bai R, Siu IM, Tyler BM, Staedtke V, Gallia GL, Riggins GJ
      Neuro Oncol  2010

      概要を表示する
      20511190 20511190

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies