数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

393207 Sigma-AldrichAnti-HNE-Michael Adducts, Reduced Rabbit pAb

Anti-HNE-Michael Adducts, Reduced, rabbit polyclonal, specifically recognizes chemically reduced amino acid-(4)-HNE adducts. It is validated for use in ELISA, WB & IHC (frozen & paraffin sections).

Anti-HNE-Michael Adducts, Reduced Rabbit pAb: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: Anti-4-Hydroxy-2-noneal Michael Adducts, Reduced

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概要

Replacement Information

主要スペック表

Species Reactivity	Host	Antibody Type
A Broad Range Of Species	Rb	Polyclonal Antibody

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
393207-100ULCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	100 ul	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	Recognizes chemically reduced amino acid-(4)-HNE adducts. Does not recognize non-reduced adducts or reduced modifications arising from malondialdehyde (MDA) and structurally-related alkenes such as trans-2-noneal.
Catalogue Number	393207
Brand Family	Calbiochem®
Synonyms	Anti-4-Hydroxy-2-noneal Michael Adducts, Reduced

References
References	Toyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681. Neely, M.D., et al. 1999. J. Neurochem. 72, 2323. Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068. Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241. Uchida, K., et al. 1994. Biochemistry 33, 12487.

Product Information
Form	Liquid
Formulation	Serum diluted in 50% glycerol, pH 7.5.
Preservative	None
Quality Level	MQ100

Applications
Key Applications	Enzyme-Linked Immunosorbent Assay Frozen Sections Immunoblotting (Western Blotting) Paraffin Sections
Application Notes	ELISA (1:500-1:1000) Immunoblotting (1:1000-1:4000) Frozen Sections (1:50-1:500) Paraffin Sections (1:50-1:500)
Application Comments	Does not bind non-reduced adducts and reduced modifications arising from malondialdehyde (MDA) or structurally-related alkenals such as trans-2-noneal. Does not cross-react with non-reduced amino acid-HNE Michael adducts. Antibody binding requires the presence of the 4-hydroxyl group. Variables associated with assay conditions will dictate the optimal working dilution.

Biological Information
Immunogen	HNE-treated KLH in which 1:1 amino acid-HNE Michael adducts were chemically reduced
Host	Rabbit
Isotype	IgG
Species Reactivity	A Broad Range Of Species
Antibody Type	Polyclonal Antibody

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
393207-100ULCN	04055977212495

Documentation

Anti-HNE-Michael Adducts, Reduced Rabbit pAb (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Anti-HNE-Michael Adducts, Reduced Rabbit pAb 試験成績書（CoA）

タイトル	ロット番号
393207	ロット番号を入力

参考資料

参考資料の概要
Toyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681. Neely, M.D., et al. 1999. J. Neurochem. 72, 2323. Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068. Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241. Uchida, K., et al. 1994. Biochemistry 33, 12487.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-August-2007 RFH
Synonyms	Anti-4-Hydroxy-2-noneal Michael Adducts, Reduced
Application	ELISA (1:500-1:1000) Immunoblotting (1:1000-1:4000) Frozen Sections (1:50-1:500) Paraffin Sections (1:50-1:500)
Description	Rabbit polyclonal antibody supplied as diluted serum. Recognizes, specifically, chemically reduced amino acid-(4)-HNE adducts.
Background	The CNS is enriched in polyunsaturated fatty acids and is therefore particularly vulnerable to lipid peroxidation. 4-Hydroxy-2-noneal (HNE) is one of the major lipid peroxidation products with cytotoxic and mutagenic activity. It reacts with protein residues such as histidine to generate stable Michael adducts. HNE has been shown to inhibit neurite outgrowth and disrupt microtubules and tubulin modification, suggesting it may play a role in Alzheimer's disease.
Host	Rabbit
Immunogen	HNE-treated KLH in which 1:1 amino acid-HNE Michael adducts were chemically reduced
Isotype	IgG
Species	a broad range of species
Form	Liquid
Formulation	Serum diluted in 50% glycerol, pH 7.5.
Preservative	None
Comments	Does not bind non-reduced adducts and reduced modifications arising from malondialdehyde (MDA) or structurally-related alkenals such as trans-2-noneal. Does not cross-react with non-reduced amino acid-HNE Michael adducts. Antibody binding requires the presence of the 4-hydroxyl group. Variables associated with assay conditions will dictate the optimal working dilution.
Storage	Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Standard Handling
References	Toyokuni, S., et al. 2000. Antioxid. Redox. Signal 2, 681. Neely, M.D., et al. 1999. J. Neurochem. 72, 2323. Uchida, K., et al. 1995. Biochem. Biophys. Res. Commun. 212, 1068. Uchida, K., et al. 1995. Arch. Biochem. Biophys. 324, 241. Uchida, K., et al. 1994. Biochemistry 33, 12487.

カテゴリー

Life Science Research > Antibodies and Assays > Primary Antibodies

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