Millipore Sigma Vibrant Logo

AB4073 Anti-Farnesyl Antibody

View This Product on Sigma-Aldrich
AB4073
100 µg  
価格を検索中…
価格が見つかりません
Minimum Quantity needs to be mulitiple of
Maximum Quantity is
弊社照会 詳細を表示 
値引
()
 
弊社照会
現在国内在庫なし
現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      Special Offers[海外情報]

       

      お問合せください

      概要

      Replacement Information

      Special Offers[海外情報]

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      AELISA, IFRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB4073
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Farnesyl Antibody
      Background InformationProtein isoprenylation is a post-translational modification that affects about 0.5% of cellular proteins and is essential for the biological activity of proteins. Two enzymes catalyze theattachment of two prenyl groups to the sulfhydryl group of carboxyl-terminal cysteine groups. Proteins which are prenylated by these enzymes have a distinct motif at the C-terminal of the protein, C-A1-A2-X (C = Cysteine, A 1 & A2 = aliphatic amino acids). The two enzymes involved in this transfer are farnesyltransferase and geranylgeranyltransferase. These transfer a 15 carbon farnesyl or a 20 carbon geranygeranyl, respectively, from aprenyl-pyrophosphate to the protein. Examples of proteins containing this C-A-A-X motif are members of the Ras small G protein family, the nuclear lamins and the gamma subunit oftrimeric G proteins. Prenylation of proteins is necessary for membrane association of proteins as well as protein-protein interactions and the nature of the linked isoprenyl group can influence the protein interactions, such as the interaction between G proteins and receptors.
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Sterile liquid in phosphate buffered saline and 0.08% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Farnesyl Antibody detects level of Farnesyl & has been published & validated for use in ELISA & IF.
      Key Applications
      • ELISA
      • Immunofluorescence
      Application NotesELISA

      Immunofluoresecence

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenAntibody developed using farnesyl cysteine conjugated to KLH.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes farnesyl motif derived from isoprenylated C-A-A-X sequence. Also cross-reacts with geranylgeranyl motif. Detects KLH as well.
      Species Reactivity
      • All
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      AB4073 04053252678721

      Documentation

      Anti-Farnesyl Antibody (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-Farnesyl Antibody 試験成績書(CoA)

      タイトルロット番号
      RABBIT ANTI-FARNESYL - 2483171 2483171
      RABBIT ANTI-FARNESYL POLYCLONAL ANTIBODY - 2343538 2343538
      RABBIT ANTI-FARNESYL POLYCLONAL ANTIBODY - 2424467 2424467
      RABBIT ANTI-FARNESYL - 3167098 3167098
      RABBIT ANTI-FARNESYL - 3214398 3214398
      RABBIT ANTI-FARNESYL - 3233136 3233136
      RABBIT ANTI-FARNESYL - 3425037 3425037
      RABBIT ANTI-FARNESYL - 3514274 3514274
      RABBIT ANTI-FARNESYL - 3740950 3740950
      RABBIT ANTI-FARNESYL - 3821669 3821669

      参考資料

      参考資料の概要Pub Med ID
      Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
      Yang, W; Yamada, M; Tamura, Y; Chang, K; Mao, J; Zou, L; Feng, Y; Kida, K; Scherrer-Crosbie, M; Chao, W; Ichinose, F; Yu, YM; Fischman, AJ; Tompkins, RG; Yao, S; Kaneki, M
      The Journal of pharmacology and experimental therapeutics  339  832-41  2011

      概要を表示する
      21873557 21873557
      RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody.
      Baron, R, et al.
      Proc. Natl. Acad. Sci. U.S.A., 97: 11626-31 (2000)  2000

      概要を表示する
      11027361 11027361
      Isoprenylation of polypeptides in the nematode Caenorhabditis elegans.
      Aspbury, R A, et al.
      Biochim. Biophys. Acta, 1392: 265-75 (1998)  1998

      概要を表示する
      9630668 9630668