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129876 Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem

An inhibitor of angiogenesis.

Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I

Primary Target: capillary morphogenesis
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129876
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
2016-88-8C₆H₈ClN₇O • HCl

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カタログ番号 在庫状況包装 Qty/Pk 価格 数量
129876-100MGCN
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      		 ｱﾙﾐﾆｳﾑｶﾝ 100 mg
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      Description
      OverviewAn inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
      Catalogue Number129876
      Brand Family Calbiochem®
      SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
      References
      ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
      Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
      Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
      Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
      Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
      Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
      Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
      Product Information
      CAS number2016-88-8
      ATP CompetitiveN
      FormOff-white to yellow solid
      Hill FormulaC₆H₈ClN₇O • HCl
      Chemical formulaC₆H₈ClN₇O • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcapillary morphogenesis
      Primary Target IC<sub>50</sub>130 µM inhibiting capillary morphogenesis completely and reversibly
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUQ2275500
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 45-36

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      129876-100MGCN 04055977222289

      Documentation

      Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      129876

      参考資料

      参考資料の概要
      Knoll, A., et al. 1999. Microvasc. Res. 58, 1.
      Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
      Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
      Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
      Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
      Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
      Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-April-2009 JSW
      SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
      DescriptionAn inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
      FormOff-white to yellow solid
      CAS number2016-88-8
      RTECSUQ2275500
      Chemical formulaC₆H₈ClN₇O • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (2.5 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 406
      ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
      Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
      Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
      Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
      Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
      Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
      Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.