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96-Well Plate
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option（チェックを入れると箱詰めから袋詰めに変更となりますのでご注意ください） Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
Catalogue Number
114825
Brand Family
Calbiochem®
Synonyms
CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
References
References
Irby, C.E., et al. 2008. J. Adolesc. Health43, 421. Ocker, M., et al. 2003. Int. J. Cancer107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol.114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol.36, S96.
Adapalene - CAS 106685-40-9 - Calbiochem 試験成績書（CoA）
タイトル
ロット番号
114825
参考資料
参考資料の概要
Irby, C.E., et al. 2008. J. Adolesc. Health43, 421. Ocker, M., et al. 2003. Int. J. Cancer107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol.114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol.36, S96.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
01-September-2010 RFH
Synonyms
CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271
Description
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
106685-40-9
Chemical formula
C₂₈H₂₈O₃
Structure formula
Purity
≥97% by HPLC
Solubility
DMSO (12 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Irby, C.E., et al. 2008. J. Adolesc. Health43, 421. Ocker, M., et al. 2003. Int. J. Cancer107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol.114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol.36, S96.
