Millipore Sigma Vibrant Logo

208719 ALLN - CAS 110044-82-1 - Calbiochem

ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).

ALLN - CAS 110044-82-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V

Primary Target: Calpain-1
View This Product on Sigma-Aldrich
208719
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
110044-82-1C₂₀H₃₇N₃O₄

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
208719-25MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 25 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      208719-5MGCN
      在庫状況検索中…
      —
      現在国内在庫なし 現在国内在庫なし
      現在国内在庫有り 
      販売中止
      在庫僅少
      現在国内在庫あり
        Remaining : Will advise
          Remaining : Will advise
          注文対象外
          お問合せください
          Contact Customer Service

          		 樹脂ｱﾝﾌﾟﾙ 5 mg
          価格を検索中…
          価格が見つかりません
          Minimum Quantity needs to be mulitiple of
          Maximum Quantity is
          弊社照会 詳細を表示　
          値引
          ()
           
          —
          弊社照会
          		 —
          Description
          OverviewCell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
          Catalogue Number208719
          Brand Family Calbiochem®
          SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
          References
          ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
          Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
          Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
          Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
          Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
          Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
          Product Information
          CAS number110044-82-1
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₀H₃₇N₃O₄
          Chemical formulaC₂₀H₃₇N₃O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
          Biological Information
          Primary TargetCalpain-1
          Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          208719-25MGCN 04055977202656
          208719-5MGCN 04055977202663

          Documentation

          ALLN - CAS 110044-82-1 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          ALLN - CAS 110044-82-1 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          208719

          参考資料

          参考資料の概要
          Debiasi, R.L., et al. 1999. J. Virol. 73, 695.
          Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
          Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
          Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
          Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
          Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

          カタログ

          タイトル
          Caspases and other Apoptosis Related Tools Brochure
          Proteasomes Technical Bulletin

          引用

          Title
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
          		•
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
          DescriptionInhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex.
          FormWhite to off-white solid
          CAS number110044-82-1
          Chemical formulaC₂₀H₃₇N₃O₄
          Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
          Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
          Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
          Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
          Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
          Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
          Citation
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
          		•

          関連製品＆アプリケーション

          Related Products

          カタログ番号 説明  
          208721 ALLM - CAS 110115-07-6 - Calbiochem 価格＆在庫状況を表示
          208722 Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem 価格＆在庫状況を表示
          208724 Calpain Inhibitor IV - Calbiochem 価格＆在庫状況を表示

          カテゴリー

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors