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658401 AG 490 - CAS 133550-30-8 - Calbiochem

A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM).

AG 490 - CAS 133550-30-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: α-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI

Primary Target: epidermal growth factor receptor kinase autophosphorylation
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658401
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
133550-30-8C₁₇H₁₄N₂O₃

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      Description
      OverviewA cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Inhibition of JAK2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658411) in DMSO is also available.
      Catalogue Number658401
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
      References
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Eriksen, K.W., et al. 2001. Leukemia 15, 787.
      Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
      Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
      Meydan, N., et al. 1996. Nature 379, 645.
      Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Product Information
      CAS number133550-30-8
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₇H₁₄N₂O₃
      Chemical formulaC₁₇H₁₄N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetepidermal growth factor receptor kinase autophosphorylation
      Primary Target IC<sub>50</sub>100 nM against epidermal growth factor receptor kinase autophosphorylation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      658401-5MGCN 07790788052218

      Documentation

      AG 490 - CAS 133550-30-8 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      AG 490 - CAS 133550-30-8 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      658401

      参考資料

      参考資料の概要
      Jaleel, M., et al. 2004. Biochemistry 43, 8247.
      Eriksen, K.W., et al. 2001. Leukemia 15, 787.
      Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
      Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
      Meydan, N., et al. 1996. Nature 379, 645.
      Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.

      カタログ

      タイトル
      An Introduction to Inhibitors and Their Biological Applications - 1st Edition
      Caspases and other Apoptosis Related Tools Brochure

      Posters

      タイトル
      Human Kinome & InhibitorSelect™ Libraries

      引用

      Title
    • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.
      		•
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonymsα-Cyano-(3,4-dihydroxy)-N-benzylcinnamide, Tyrphostin B42, (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
      DescriptionA cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
      FormYellow solid
      CAS number133550-30-8
      Chemical formulaC₁₇H₁₄N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Toxicity Standard Handling
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Eriksen, K.W., et al. 2001. Leukemia 15, 787.
      Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
      Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
      Meydan, N., et al. 1996. Nature 379, 645.
      Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Citation
    • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.
      		•