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658452 AG 126 - CAS 118409-62-4 - Calbiochem

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

AG 126 - CAS 118409-62-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile

Primary Target: COX-2 activity
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658452
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
118409-62-4C₁₀H₅N₃O₃

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      		 ｱﾙﾐﾆｳﾑｶﾝ 5 mg
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      Description
      OverviewA cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
      Catalogue Number658452
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
      References
      ReferencesCuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
      Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
      Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
      Novogrodsky, A., et al. 1994. Science 264, 1319.
      Product Information
      CAS number118409-62-4
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₀H₅N₃O₃
      Chemical formulaC₁₀H₅N₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-2 activity
      Primary Target IC<sub>50</sub>15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      658452-5MGCN 04055977261622

      Documentation

      AG 126 - CAS 118409-62-4 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      AG 126 - CAS 118409-62-4 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      658452

      参考資料

      参考資料の概要
      Cuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
      Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
      Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
      Novogrodsky, A., et al. 1994. Science 264, 1319.

      カタログ

      タイトル
      Pathways and Biomarkers of Oxidative Stress
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      Synonymsα-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
      DescriptionA cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.
      FormYellow solid
      CAS number118409-62-4
      Chemical formulaC₁₀H₅N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMF or DMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Toxic
      ReferencesCuzzocrea, S., et al. 2000. Am. J. Pathol. 157, 145.
      Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol. 77, 138.
      Kan, H., et al. 1996. Mol. Pharmacol. 50, 1139.
      Novogrodsky, A., et al. 1994. Science 264, 1319.