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287891 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem

A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC₅₀ = 6 µM).

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII

Primary Target: casein kinase II
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287891
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
53-85-0C₁₂H₁₂Cl₂N₂O₄

価格＆在庫状況

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287891-50MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 50 mg
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      Description
      OverviewA potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest.
      Catalogue Number287891
      Brand Family Calbiochem®
      Synonyms5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
      References
      ReferencesKim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
      Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
      Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
      Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
      Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
      Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
      Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
      Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.
      Product Information
      CAS number53-85-0
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₂H₁₂Cl₂N₂O₄
      Chemical formulaC₁₂H₁₂Cl₂N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcasein kinase II
      Primary Target IC<sub>50</sub>6 µM
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDD7310000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsRoom temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      287891-50MGCN 04055977197884

      Documentation

      5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole - CAS 53-85-0 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      287891

      参考資料

      参考資料の概要
      Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
      Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
      Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
      Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
      Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
      Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
      Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
      Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2009 RFH
      Synonyms5,6-Dichlorobenzimidazole Riboside, DRB, Casein Kinase II Inhibitor VII
      DescriptionAccentuates premature termination of transcription close to the promoter. Useful for isolation of RNA sequences near promoter sites that are responsible for mRNA formation. Useful for reversible superinduction of human fibroblast cultures. Potent, ATP-competivie and specific inhibitor of casein kinase II (IC50 = 6 µM). Has been used to inhibit RNA polymerase II transcription, which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes.
      FormWhite solid
      CAS number53-85-0
      RTECSDD7310000
      Chemical formulaC₁₂H₁₂Cl₂N₂O₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (3 mg/ml) or Ethanol (3 mg/ml). May require warming (47°C) to achieve complete dissolution.
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsRoom temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
      Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev. 37, 284.
      Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
      Zandomeni, R., et al. 1986. J. Biol. Chem. 261, 3414.
      Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
      Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
      Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 3167.
      Stewart, M.W., et al. 1977. J. Gen. Virol. 37, 221.