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288104 2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem

Cell-permeable, non-competitive adenylate cyclase inhibitor (IC₅₀ = 3 µM), that binds to the adenosine P1 binding site.

2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 2ʹ,5ʹ-dd-Ado

Primary Target: adenylate cyclase
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288104
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
6698-26-6C₁₀H₁₃N₅O₂

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288104-1MGCN
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      Description
      OverviewCell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of β-adrenergic agents.
      Catalogue Number288104
      Brand Family Calbiochem®
      Synonyms2ʹ,5ʹ-dd-Ado
      References
      ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
      Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
      Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
      Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
      Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
      Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
      Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.
      Product Information
      CAS number6698-26-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₃N₅O₂
      Chemical formulaC₁₀H₁₃N₅O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetadenylate cyclase
      Primary Target IC<sub>50</sub>3 µM against adenylate cyclase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      288104-1MGCN 04055977197914

      Documentation

      2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      288104

      参考資料

      参考資料の概要
      Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
      Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
      Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
      Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
      Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
      Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
      Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

      カタログ

      タイトル
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2008 RFH
      Synonyms2ʹ,5ʹ-dd-Ado
      DescriptionMembrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC50 = 3 µM for detergent solubilized rat brain membranes; IC50 = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC50 = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of β-adrenergic agents.
      FormWhite solid
      CAS number6698-26-6
      Chemical formulaC₁₀H₁₃N₅O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
      Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
      Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
      Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
      Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
      Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
      Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.