Millipore Sigma Vibrant Logo

100068 17-AAG - CAS 75747-14-7 - Calbiochem

A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus.

17-AAG - CAS 75747-14-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin

Primary Target: Hsp90
View This Product on Sigma-Aldrich
100068
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
75747-14-7C₃₁H₄₃N₃O₈

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
100068-500UGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 500 μg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
      Catalogue Number100068
      Brand Family Calbiochem®
      SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
      References
      ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
      Clarke, P.A., et al. 2002. Oncogene 19, 4125.
      Clarke, P.A., et al. 2000. Oncogene 19, 4125.
      Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
      Product Information
      CAS number75747-14-7
      ATP CompetitiveN
      FormPurple solid
      Hill FormulaC₃₁H₄₃N₃O₈
      Chemical formulaC₃₁H₄₃N₃O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHsp90
      Primary Target IC<sub>50</sub>EC50 = 7.2 µM for Hsp90
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      100068-500UGCN 04055977226881

      Documentation

      17-AAG - CAS 75747-14-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      17-AAG - CAS 75747-14-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      100068

      参考資料

      参考資料の概要
      Basso, A.D., et al. 2002. Oncogene 21, 1159.
      Clarke, P.A., et al. 2002. Oncogene 19, 4125.
      Clarke, P.A., et al. 2000. Oncogene 19, 4125.
      Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

      技術情報

      タイトル
      テクニカルデータシート: 100068 GranuCult BOLTON 基礎ブイヨン （ISO 10272準拠）

      データシート

      タイトル
      Data Sheet 1.00068.0500

      ユーザーガイド

      タイトル
      Pack insert Bolton Broth Selective Supplement 1.00079.0010
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
      DescriptionA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Reported to induce apoptosis and exhibit anti-tumor properties (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53, (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt. Hence, inhibits the Ras/Raf/MEK and PI3-Kinase signaling pathways. Shown to sensitize cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380), and down-regulates vascular endothelial factor expression.
      FormPurple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number75747-14-7
      Chemical formulaC₃₁H₄₃N₃O₈
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
      Clarke, P.A., et al. 2002. Oncogene 19, 4125.
      Clarke, P.A., et al. 2000. Oncogene 19, 4125.
      Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

      関連製品＆アプリケーション

      Accessories (Primary)

      カタログ番号 説明  
      100070 カンピロバクター無血液選択寒天基礎培地 (CCDA変法) 価格＆在庫状況を表示
      100079 ボルトンブイヨン選択剤 価格＆在庫状況を表示
      104143 Singlepath® Campylobacter 価格＆在庫状況を表示

      Accessories (Secondary)

      カタログ番号 説明  
      100079 ボルトンブイヨン選択剤 価格＆在庫状況を表示
      104143 Singlepath® Campylobacter 価格＆在庫状況を表示

      カテゴリー

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Heat Shock Protein Inhibitors