Millipore Sigma Vibrant Logo

530583 α-Synuclein Blocker, ELN484228 - CAS 312-63-0 - Calbiochem

A cell-permeable compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells.

α-Synuclein Blocker, ELN484228 - CAS 312-63-0 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: N-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228

Primary Target: monomeric α-synuclein
View This Product on Sigma-Aldrich
530583
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
312-63-0C₁₂H₁₀FNO₂S

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
5.30583.0001
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 ｶﾞﾗｽﾋﾞﾝ 25 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type α-syn and microglia isolated from α-syn BAC transgenic animals over-expressing the E46K mutant form of human α-syn (~1-10 µM). Reduces α-syn-mediated impairment of vesicular dynamics and diminishes α-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µM) and in cortical cultures in transgenic mice over-expressing human α-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed α-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530583
      Brand Family Calbiochem®
      SynonymsN-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228
      References
      ReferencesToth, G., et al. 2014. PLoS ONE 9, e87133.
      Product Information
      CAS number312-63-0
      FormOff-white solid
      Hill FormulaC₁₂H₁₀FNO₂S
      Chemical formulaC₁₂H₁₀FNO₂S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetmonomeric α-synuclein
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      5.30583.0001 04055977260915

      Documentation

      α-Synuclein Blocker, ELN484228 - CAS 312-63-0 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      参考資料

      参考資料の概要
      Toth, G., et al. 2014. PLoS ONE 9, e87133.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-May-2014 JSW
      SynonymsN-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228
      DescriptionA cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type α-syn and microglia isolated from α-syn BAC transgenic animals over-expressing the E46K mutant form of human α-syn (~1-10 µM). Reduces α-syn-mediated impairment of vesicular dynamics and diminishes α-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µM) and in cortical cultures in transgenic mice over-expressing human α-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed α-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number312-63-0
      Chemical formulaC₁₂H₁₀FNO₂S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesToth, G., et al. 2014. PLoS ONE 9, e87133.