数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565790 Sigma-Aldrichγ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem

This g-secretase inhibitor, CAS 209986-17-4, is a cell-permeable, potent, selective, non-transition-state analog inhibitor of γ-secretase and Notch processing. Lowers Aβ levels in APP transgenic mice

γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: (S,S)- 2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide, Compound E

Primary Target: γ-secretase and Notch processing Ab40 in CHO cells overexpressing wild type bAPP

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
209986-17-4	C₂₇H₂₄F₂N₄O₃

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
565790-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	ｶﾞﾗｽﾋﾞﾝ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
565790-500UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	500 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing (IC₅₀ = 300 pM for Aβ₄₀ in CHO cells overexpressing wild type βAPP; 240 pM for Aβ₄₀, 370 pM for Aβ₄₂, and 320 pM for NICD, respectively, in HEK293 cells stably transfected with βAPP₆₉₅ and mNotchΔE(M1727V); 100 pM for both Aβ₄₀ and Aβ₄₂ in SH-SY5Y cells stably transfected with SPA4CT). Lowers Aβ levels in several APP transgenic mouse models. Reported to bind to presenilins and suppress the proteolytic cleavage of transmembrane protein substrates, including APLP1 and APLP2, CD44, ErbB4, E-cadherin, low density lipoprotein receptor-related proteins, Notch ligands, and p75^NTR. Only weakly affects presenilinase activity at much higher concentrations (200-400 µM).
Catalogue Number	565790
Brand Family	Calbiochem®
Synonyms	(S,S)- 2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide, Compound E

References
References	Milano, J., et al. 2004. Toxicol. Sci. 82, 341. Jung, K.M., et al. 2003. J. Biol. Chem. 278, 42161. Murakami, D., et al. 2003. Oncogene 22, 1511. Campbell, W.A., et al. 2003. J. Neurochem. 85, 1563. Berechid, B.E., et al., 2002. J. Biol. Chem. 277, 8154. Lee, H.J., et al. 2002. J. Biol. Chem. 277, 6318. May, P., et al. 2002. J. Biol. Chem. 277, 18736. Scheinfeld, M.H., et al. 2002. J. Biol. Chem. 277, 44195. Ni, C. Y., et al. 2001. Science 294, 2179. Beher, D., et al. 2001. J. Biol. Chem. 276, 45394. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Seiffert, D., et al. 2000. J. Biol. Chem. 275, 34086.

References

Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
Jung, K.M., et al. 2003. J. Biol. Chem. 278, 42161.
Murakami, D., et al. 2003. Oncogene 22, 1511.
Campbell, W.A., et al. 2003. J. Neurochem. 85, 1563.
Berechid, B.E., et al., 2002. J. Biol. Chem. 277, 8154.
Lee, H.J., et al. 2002. J. Biol. Chem. 277, 6318.
May, P., et al. 2002. J. Biol. Chem. 277, 18736.
Scheinfeld, M.H., et al. 2002. J. Biol. Chem. 277, 44195.
Ni, C. Y., et al. 2001. Science 294, 2179.
Beher, D., et al. 2001. J. Biol. Chem. 276, 45394.
Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312.
Seiffert, D., et al. 2000. J. Biol. Chem. 275, 34086.

Product Information
CAS number	209986-17-4
ATP Competitive	N
Form	White solid
Hill Formula	C₂₇H₂₄F₂N₄O₃
Chemical formula	C₂₇H₂₄F₂N₄O₃
Reversible	N
Structure formula Image

Applications

Biological Information
Primary Target	γ-secretase and Notch processing Ab40 in CHO cells overexpressing wild type bAPP
Primary Target IC<sub>50</sub>	300 pM for Aβ40 in CHO cells overexpressing wild typeβAPP; 240 pM for Aβ40, 370 pM for Aβ42, and 320 pM for NICD, respectively, in HEK293 cells stably transfected with βAPP695 and mNotchΔE(M1727V); 100 pM for both Aβ40
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
565790-1MGCN	04055977191851
565790-500UGCN	04055977191868

Documentation

γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
565790	ロット番号を入力

参考資料

参考資料の概要
Milano, J., et al. 2004. Toxicol. Sci. 82, 341. Jung, K.M., et al. 2003. J. Biol. Chem. 278, 42161. Murakami, D., et al. 2003. Oncogene 22, 1511. Campbell, W.A., et al. 2003. J. Neurochem. 85, 1563. Berechid, B.E., et al., 2002. J. Biol. Chem. 277, 8154. Lee, H.J., et al. 2002. J. Biol. Chem. 277, 6318. May, P., et al. 2002. J. Biol. Chem. 277, 18736. Scheinfeld, M.H., et al. 2002. J. Biol. Chem. 277, 44195. Ni, C. Y., et al. 2001. Science 294, 2179. Beher, D., et al. 2001. J. Biol. Chem. 276, 45394. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Seiffert, D., et al. 2000. J. Biol. Chem. 275, 34086.

参考資料の概要

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2011 RFH
Synonyms	(S,S)- 2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide, Compound E
Description	A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of γ-secretase and Notch processing (IC₅₀ = 300 pM for Aβ₄₀ in CHO cells overexpressing wild type βAPP; 240 pM for Aβ₄₀, 370 pM for Aβ₄₂, and 320 pM for NICD, respectively, in HEK293 cells stably transfected with βAPP₆₉₅ and mNotchΔE(M1727V); 100 pM for both Aβ₄₀ and Aβ₄₂ in SH-SY5Y cells stably transfected with SPA4CT). Lowers Aβ levels in several APP transgenic mouse models. Reported to bind to presenilins and suppress the proteolytic cleavage of transmembrane protein substrates, including APLP1 and APLP2, CD44, ErbB4, E-cadherin, low density lipoprotein receptor-related proteins, Notch ligands, and p75^NTR. Only weakly affects presenilinase activity at much higher concentrations (200-400 µM).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	209986-17-4
Chemical formula	C₂₇H₂₄F₂N₄O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Milano, J., et al. 2004. Toxicol. Sci. 82, 341. Jung, K.M., et al. 2003. J. Biol. Chem. 278, 42161. Murakami, D., et al. 2003. Oncogene 22, 1511. Campbell, W.A., et al. 2003. J. Neurochem. 85, 1563. Berechid, B.E., et al., 2002. J. Biol. Chem. 277, 8154. Lee, H.J., et al. 2002. J. Biol. Chem. 277, 6318. May, P., et al. 2002. J. Biol. Chem. 277, 18736. Scheinfeld, M.H., et al. 2002. J. Biol. Chem. 277, 44195. Ni, C. Y., et al. 2001. Science 294, 2179. Beher, D., et al. 2001. J. Biol. Chem. 276, 45394. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Seiffert, D., et al. 2000. J. Biol. Chem. 275, 34086.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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