数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565789 Sigma-Aldrichγ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem

This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet
Citations

同義語: (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine

Primary Target: γ-secretase

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
209984-56-5	C₂₆H₂₃F₂N₃O₃

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
565789-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	ｶﾞﾗｽﾋﾞﾝ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
565789-500UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	500 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ₄₀ levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC₅₀ = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and Apc^Min mouse models (10 µmol/kg, i.p).
Catalogue Number	565789
Brand Family	Calbiochem®
Synonyms	(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine

References
References	Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341.

Product Information
CAS number	209984-56-5
ATP Competitive	N
Form	White solid
Hill Formula	C₂₆H₂₃F₂N₃O₃
Chemical formula	C₂₆H₂₃F₂N₃O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	γ-secretase
Primary Target IC<sub>50</sub>	1.7 nM inhibiting Notch processing in SupT1 cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
565789-1MGCN	04055977191837
565789-500UGCN	04055977191844

Documentation

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
565789	ロット番号を入力

参考資料

参考資料の概要
Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341.

引用

Title

Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2012 RFH
Synonyms	(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
Description	A cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ₄₀ levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC₅₀ = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and Apc^Min mouse models (10 µmol/kg, i.p).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	209984-56-5
Chemical formula	C₂₆H₂₃F₂N₃O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107. van Es, J.H., et al. 2005. Nature 435, 959. Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
Citation	Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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