Millipore Sigma Vibrant Logo

565763 γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem

The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide

Primary Target: Aβ₄₂ production
View This Product on Sigma-Aldrich
565763
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
287196-57-0C₁₆H₂₂FNO₂S

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
565763-5MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 5 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewCell permeable. Potently inhibits Aβ42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
      Catalogue Number565763
      Brand Family Calbiochem®
      Synonyms1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
      References
      ReferencesRishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.
      Product Information
      CAS number287196-57-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₂₂FNO₂S
      Chemical formulaC₁₆H₂₂FNO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAβ₄₂ production
      Primary Target IC<sub>50</sub>1.8 µM against Aβ42 production
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      565763-5MGCN 04055977267723

      Documentation

      γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      γ-Secretase Inhibitor VI - CAS 287196-57-0 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      565763

      参考資料

      参考資料の概要
      Rishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
      DescriptionA potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ42 (IC50 = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APPSα, but no change in secreted APPSβ, indicating a specific inhibition of γ-secretase activity.
      FormWhite solid
      CAS number287196-57-0
      Chemical formulaC₁₆H₂₂FNO₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRishton, G.M., et al. 2000. J. Med. Chem. 43, 2297.