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565749 β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal

Primary Target: β-secretase
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565749
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
263563-09-3C₂₅H₃₉N₃O₅

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
565749-1MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 mg
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      565749-5MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 5 mg
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          Description
          OverviewA potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.
          Catalogue Number565749
          Brand Family Calbiochem®
          SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
          References
          ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
          Product Information
          CAS number263563-09-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₅H₃₉N₃O₅
          Chemical formulaC₂₅H₃₉N₃O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetβ-secretase
          Primary Target IC<sub>50</sub>700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Val-Leu-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          565749-1MGCN 04055977267655
          565749-5MGCN 04055977267662

          Documentation

          β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          β-Secretase Inhibitor II - CAS 263563-09-3 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          565749

          参考資料

          参考資料の概要
          Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          SynonymsZ-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
          DescriptionA potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number263563-09-3
          Chemical formulaC₂₅H₃₉N₃O₅
          Peptide SequenceZ-Val-Leu-Leu-CHO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAbbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.